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FPGEE exam Format | FPGEE Course Contents | FPGEE Course Outline | FPGEE exam Syllabus | FPGEE exam Objectives


The Foreign Pharmacy Graduate Equivalency Exam®, or FPGEE®, is one of the examinations required as part of the FPGEC Certification Program (You must also take and pass the TOEFL iBT, the English-language exam administered by Educational Testing Service. Applications submitted after January 1, 2020 must complete the TOEFL iBT requirement prior to sitting for the FPGEE).



The FPGEE is offered once per year, and it is administered at Pearson VUE test sites throughout the continental United States. Only individuals made eligible during the FPGEC application process can take the FPGEE.



You will be notified via your e-Profile that you are eligible to sit for the FPGEE after successfully completing the FPGEC evaluation process. You must pass the FPGEE within two years of having your FPGEC application accepted or your application will expire, and you will need to submit a new FPGEC application.



An overview of FPGEC Certification

FPGEC and ECE application procedures

Documentation of pharmacist credentials

Registering for the FPGEE

FPGEE administration

FPGEE score results



The FPGEE Competency Statements provide a blueprint of the Topics covered on the examination. A strong understanding of the Competency Statements will aid in your preparation to take the examination. The 200 questions on the FPGEE are divided among four content areas:



Basic biomedical sciences – 10%

Pharmaceutical sciences – 33%

Social, behavioral, administrative pharmacy sciences – 22%

Clinical sciences – 35%

The statements can be found in the FPGEC Candidate Application Bulletin.



Foreign Pharmacy Graduate exam Committee™ (FPGEC®) Certification is required for
foreign-educated pharmacists seeking to apply for the pharmacy licensing exams (including the North
American Pharmacist Licensing Exam® (NAPLEX®) and Multistate Pharmacy Jurisprudence
Exam® (MPJE®)) in the United States and NABP member jurisdictions. To obtain FPGEC
Certification, a candidate must have their required documentation and application accepted, including
a passing score on the Test of English as a Foreign Language Internet-based Test (TOEFL iBT), and
pass the Foreign Pharmacy Graduate Equivalency Exam® (FPGEE®). The information below is
provided to guide you through the key steps in applying for FPGEC Certification, including instructions
for registering to take the FPGEE. It answers the most frequently asked questions about the FPGEC
application process. Please read this information carefully and refer to the appropriate sections of this
Application Bulletin for detailed information.



NABP provides the FPGEC Certification Program to document the educational equivalency of
a candidates foreign pharmacy education, as well as their license and/or registration to practice
pharmacy. To achieve FPGEC Certification, candidates must:

• Provide documents that verify their education background.

• Provide documents that verify licensure and/or registration to practice pharmacy.

• Pass the Test of English as a Foreign Language Internet-based Test (iBT).

• Pass the FPGEE.

Candidates who receive an FPGEC Certificate may be qualified to take the pharmacy licensing
examination in jurisdictions that accept this Certification. All 50 US states, the District of Columbia,
Guam, and Puerto Rico require foreign-trained pharmacists to achieve FPGEC Certification before
applying for a license from a state board of pharmacy



- Physiology

- Function of the major body systems and homeostatic impact at organ and system level

- Biochemistry

- Chemistry and utilization of biomacromolecules including proteins, lipids, carbohydrates, nucleic acid, intermediary metabolism of energy and nutritional molecules

- Enzymology and coenzymes and kinetics

- Cell chemistry, signal transduction pathways

- Transport and mobility

- Recombinant DNA and molecular biotechnology

- mRNA translation and protein synthesis

- Microbiology Related to Human Disease

- Structure, function, and characteristics of microorganisms: microbe classification, structure, metabolism, genetics

- Pathogenic microorganisms of humans

- Immunology

- Innate and adaptive immunity

- Principles of antibody actions

- Hypersensitivity and types of reactions



Area 2.0 - Pharmaceutical Sciences (Approximately 33% of Test)

- Medicinal Chemistry

- Physicochemical properties of drugs in relation to drug absorption, distribution, metabolism, and excretion (ADME)

- Chemical basis for drug action

- Fundamental pharmacophores for drugs used to treat diseases

- Structure-activity relationships in relation to drug-target interactions

- Chemical pathways of drug metabolism

- Applicability to making drug therapy decisions

- Pharmacology and Toxicology

- Mechanisms of action of drugs of various categories including biologics

- Pharmacodynamics of drug binding and response

- Adverse effects and side effects of drugs

- Mechanisms of drug-drug interactions

- Drug discovery and development

- Acute and chronic toxic effect of xenobiotics, including drug and chemical overdose and antidotes

- Pharmacognosy and Dietary Supplements

- Concepts of crude drugs, semi-purified, and purified natural products

- Classes of pharmacologically active natural products

- Science and regulation of dietary supplements (vitamins, minerals, and herbals)

- Pharmaceutics/Biopharmaceutics

- Biopharmaceutical principles of drug delivery to the body via dosage forms: liquid, solid, semisolid, controlled release, patches, implants

- Materials and methods used in preparation of drug forms

- Physicochemical properties relating to drug entities and dosage forms

- Principles of drug and dosage form stability, including chemical degradation and physical instability

- Pharmacokinetics

- Basic principles of in-vivo drug kinetics (linear and nonlinear)

- Principles of bioavailability and bioequivalence

- Physiologic determinates of drug onset and duration, including disease and dietary influences on absorption, distribution, metabolism, and excretion

- Pharmacogenomics and Genetics

- Molecular genetics, genomic, proteomic, and metabolomic principles that serve as a foundation for pharmacogenomics and the genetic basis of disease

- Genetic variants affecting drug action and metabolism, adverse drug reactions, and disease risk that influence the practice of personalized medicine

- Sterile and Nonsterile Compounding

- United States Pharmacopeia guidelines on sterile and nonsterile compounding, hazardous drugs, and FDA regulation of compounding

- Techniques and principles used to prepare and dispense individual extemporaneous prescriptions, including dating of compounded dosage forms

- Dosage form preparation calculations

- Sterile admixture techniques, including stability, clean-room requirements, sterility testing, and dating



Area 3.0 – Social/Behavioral/Administrative Sciences (Approximately 22% of Test)

- Health Care Delivery Systems and Public Health

- Organization of health care delivery systems at the national, state, and local levels: various settings where pharmacy is practiced and the structure of health care delivery systems such as managed care organizations, accountable care organizations, health departments

- Health care delivery financing in the United States

- Social, political, and economic factors that influence the delivery of health care in the United States

- Public Health and Wellness: chronic disease prevention, health promotion, infectious disease control, demographics, physical, social, and environmental factors leading to disease, comparing and contrasting public health with individual medical care

- The health care delivery system compared and contrasted with that of other industrialized nations

- Population-Based Care and Pharmacoepidemiology

- Data sources and analytic tools that provide an estimate of the probability of beneficial or adverse effects of medication use in large populations

- Application of epidemiological study designs to evaluate drug use and outcomes in large populations

- Methods for continually monitoring unwanted effects and other safety-related aspects of medication use in large populations

- Economic and Humanistic Outcomes of Health Care Delivery

- General microeconomic and general macroeconomic principles

- Pharmacoeconomic analysis and its application to Improve the allocation of limited health care resources

- Humanistic outcomes and their application to Improve the allocation of limited health care resources

- Pharmacy Practice Management

- Management principles (planning, organizing, directing, and controlling pharmacy resources) applied to various pharmacy practice setting and patient outcomes

- Personnel management

- Planning, including delineation between business and strategic planning

- Marketing of goods and services: product versus service pricing, distribution, promotion

- Accounting and financial management

- Budgeting

- Risk management

- Pharmacy Law and Regulatory Affairs

- Legal and regulatory principles applied to pharmacy practice: dispensing, professional services, drug use control

- Administrative, civil, and criminal liability

- Authority, responsibilities, and operation of agencies and entities that promulgate or administer laws, regulations, or guidances related to practice and prescription and nonprescription medications

- Biostatistics and Research Design

- Research study designs used in medical research

- Application and interpretation of statistical tests and data collection instruments

- Ethical Decision Making

- Principles of biomedical ethics

- Ethical dilemmas in the delivery of patient-centered care including, conflicts of interest, end-of-life decision making, use of codes of ethics, oaths of the pharmacist

- Research ethics

- Professional Communication

- Communication abilities (appropriate verbal, nonverbal, visual, and written) with patient and caregivers, including empathetic communication

- Communication abilities with other health care providers

- Assertiveness and problem-solving techniques in relation to difficult social and professional conflicts and situations

- Measurement and use of health literacy in pharmacy communications

- Development of cultural competency in pharmacy personnel such that services are respectful of and responsive to the health beliefs, practices, and cultural and linguistic needs of diverse patient populations

- Social and Behavioral Aspects of Pharmacy Practice

- Health-, illness-, and sick-role behaviors of patients

- Principles of behavior modification

- Patient adherence to therapies and recommendations

- Caregiving throughout the lifecycle

- Death and dying

- Medication Dispensing and Distribution Systems

- Systems for safe and effective preparation and dispensing of medications in all types of practice settings

- Role of automation and technology: pharmacy informatics, information management

- Continuous quality improvement programs or protocols in the medication-use process, including identification and prevention of medication errors, and establishment of error reduction programs



Area 4.0 – Clinical Sciences (Approximately 35% of Test)

- Evidence-based Practice

- Interpret and evaluate drug information

- Apply drug-information skills for the delivery of medication therapy management

- Evaluate the reliability of various sources of information

- Interpret guidelines as they apply in a clinical setting

- Utilize core scientific and systems-based knowledge in the patient care decision-making process

- Utilize basic science principles in the development and/or implementation of drug treatment protocols and clinical practice guidelines

- Evaluate clinical trials that validate clinical appropriateness

- Clinical Pathophysiology

- Apply concepts of pathophysiology to clinical decision making

- Clinical Pharmacokinetics

- Utilize pharmacokinetics to calculate, evaluate, and individualize drug therapy

- Interpret clinical pharmacokinetics of commonly used and low-therapeutic-index drug
s
- Clinical Pharmacogenomics

- Utilize pharmacogenomics to calculate, evaluate, and individualize drug therapy

- Disease Prevention and Population Health

- Recognize the proper use of nonpharmacologic therapies, including complementary and alternative medicines

- Describe measures to promote wellness and disease prevention

- Identify the role of immunizations in disease prevention and health promotion

- Patient Assessment

- Describe techniques for obtaining a comprehensive patient history

- Describe how to perform patient physical exams: inspection, palpation, percussion, auscultation

- Differentiate between normal physical exam findings and modifications caused by common disease states and drug therapy

- Interpret common clinical laboratory values and diagnostic tests

- Perform calculations related to patient exam: BMI, CrCl, lab adjustments

- Describe the use of OTC point-of-care testing devices: glucometers, pregnancy tests, home testing for HbA1c, drug screening

- Clinical Pharmacology and Therapeutic Decision Making

- Make therapy recommendations based on dosage calculations, specific uses and indications of drugs and nutritional and support therapy

- Interpret therapeutic drug concentrations

- Assess pharmacotherapy considering contraindications, therapeutic duplications, dietary interactions, adverse drug reactions and interactions, and allergies

- Triage and identify when to refer patients to other health professionals

- Design patient-centered, culturally-relevant treatment plans

- Apply evidence-based decision making to patient care

- Recommend nonprescription and natural product therapies

- Identify and manage drug toxicity, drug-induced diseases, and misuse or abuse

- Monitor drug therapy for misuse, abuse, and non-adherence



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7 of the biggest medical breakthroughs in 2023 | Killexams.com Resources

From new vaccines to the primary medication of their type for challenging-to-deal with disorders, 2023 has been a 12 months filled with clinical breakthroughs.

They present opportunities for americans to supply protection to themselves from ailments, slow down the outcomes of others and even include synthetic intelligence into cancer diagnoses.

listed here are seven of the largest innovations within the health and science house this year.

New RSV vaccines and immunizations

For the first time ever, after years of setbacks, there are varied vaccines and pictures accessible for several distinctive groups to steer clear of RSV.

For adults over age 60, who are at higher risk for severe problems from RSV because immune techniques weaken with age, the U.S. food and Drug Administration (FDA) permitted two vaccines.

"So a great deal focal point is positioned on flu and now COVID. however, each year in the U.S., they see tens of thousands of older adults hospitalized from RSV, hundreds die from RSV issues," mentioned Dr. John Brownstein, an epidemiologist and chief innovation officer at Boston little ones's health facility and an ABC information contributor.

"It nevertheless has large public fitness consequences for those who are most inclined, and so now having a excessive efficacy vaccine is truly an important breakthrough for the final 12 months and that i believe can have big public health improvement for years to come back," he delivered.

PHOTO: The US FDA approves GSK's Arexvy, the world's first respiratory syncytial virus ( RSV) vaccine for older adults.

the USA FDA approves GSK's Arexvy, the realm's first respiratory syncytial virus ( RSV) vaccine for older adults.

company Wire/AP

The FDA additionally authorized a maternal RSV vaccine, which is given to pregnant mothers within the third trimester between 32 weeks' and 36 weeks' gestation and is designed to pass antibodies to toddlers within the womb. it might deliver coverage from extreme ailment in the course of the first six months of existence.

finally, for infants under eight months historical, there are two monoclonal antibody photographs attainable. Monoclonal antibodies are laboratory-made proteins that mimic the body's potential to combat off pathogens. they're distinctive from vaccines, which stimulate the immune device.

1st CRISPR gene-editing approach to deal with sickle mobilephone

previous this month, the FDA authorised two gene treatments to deal with sickle telephone disease (SCD), together with the primary CRISPR gene-editing therapy.

SCD is a genetic situation through which purple blood cells have a crescent, or sickle, form, causing them to be tough and sticky.

"it's a disease that truly touches every organ in the physique," Dr. Sharl Azar, medical director of the comprehensive Sickle phone sickness treatment center at Massachusetts frequent clinic, informed ABC information. "a quarter of their sufferers will have had a stroke by the point they're of their 40s. lots of their sufferers may have had their first joint alternative by the time they're of their 30s. Many others can have had their first coronary heart attack in their 20s."

"If the disorder goes unchecked, it could possibly lead to blindness, it will probably lead to dialysis dependence and most of their patients may not see their 45th or fiftieth birthday," he continued.

One of those therapies, Lyfgenia, makes use of a bit of a virus to convey a gene for fetal hemoglobin, which prevents blood cells from sticking collectively and constricting blood move, which is delivered back into the affected person.

The other remedy, Casgevy, used CRISPR/Cas9 to genetically edit the stem cells to produce extra fetal hemoglobin, which are then also put lower back into the patient

"From a scientific and medical standpoint, both of those therapies aim to do the equal aspect, they just do it in a a little bit diverse way," Azar mentioned. "So, the critical thing to emphasize here is that these aren't a remedy for sickle phone sickness. The patients will nevertheless have sickle telephone sickness on the other side of the intervention. The hope is that they'll simply have a milder type of the ailment, the place they could see a whole lot less pain and hopefully fewer complications and hopefully even a longer lifestyles."

Over-the-counter birth control pill

In July, the FDA authorized the first over-the-counter contraception capsule, meaning it can be bought with out a prescription.

called Opill via French drugmaker HRA Pharma and its mother or father company Perrigo, public fitness consultants have talked about it'll develop contraception entry for thousands and thousands of people within the united states.

PHOTO: This illustration provided by Perrigo in May, 2023, depicts proposed packaging for the company's birth control medication Opill.

This illustration provided via Perrigo in may also, 2023, depicts proposed packaging for the company's contraception remedy Opill.

Perrigo by way of AP

Opill is a progestin-handiest pill -- occasionally called the "minipill", that means it does not include estrogen like combination contraception capsules. medical doctors say progestin-best pills pose fewer scientific dangers than mixture pills.

The drug is expected to appear on cabinets at convenience shops, grocery chains and online in early 2024.

Scientists pinpoint possible explanation for morning ailment

Morning sickness is an extremely average early symptom of being pregnant, with up to eighty% of pregnant ladies experiencing it within the first trimester -- and now researchers accept as true with they have found out the cause.

A team exceptionally from the U.S., U.okay. and Sri Lanka found a link between a hormone called GDF15, produced by means of the fetus in the placenta, and morning sickness.

results, published earlier this month in the journal Nature, discovered ladies with severe nausea and vomiting and blood degrees of GDF15 all the way through the primary trimester that had been tremendously greater compared to ladies who did not adventure sickness.

additionally, women who are more delicate to the hormone turn into the sickest, which may clarify the small percentage of women who suffer an intense type of morning sickness hyperemesis gravidarum, which is the main cause of hospitalization in the early stage of being pregnant and famously experienced with the aid of Catherine, Princess of Wales all the way through all three of her pregnancies.

Researchers mentioned the discovering might aid deal with women with morning affliction, peculiarly severe varieties, by way of lowering ranges of the hormone right through pregnancy.

First drug totally permitted via the FDA to deal with Alzheimer's

in the past, Alzheimer's ailment remedy has been marked by means of a number of drugs which have failed medical trials but, in July, the FDA granted full acclaim for a brand new drug known as Leqembi.

Manufactured with the aid of the pharmaceutical organizations Eisai and Biogen, it is the first drug of its kind that has shown to sluggish cognitive decline in early Alzheimer's sufferers.

Leqembi works by targeting amyloid beta, the leading component of the amyloid plaques found in the brains of Alzheimer's sufferers and influences memory and notion. It marks the plaques for clearance by way of the body's immune equipment, which slows Alzheimer's symptoms.

"or not it's a big milestone in Alzheimer's ailment medication," Brownstein noted. "it is a very large step in giving individuals littered with this ailment more time, and scientific trials have proven to modestly gradual cognitive decline, in particular in individuals with early Alzheimer's sickness, and so with the aid of slowing cognitive decline, that drug might supply people more time to engage in actions that they delight in."

PHOTO: This Dec. 21, 2022, image provided by Eisai in January 2023, shows vials and packaging for their medication Leqembi.

This Dec. 21, 2022, graphic supplied by Eisai in January 2023, shows vials and packaging for his or her treatment Leqembi.

Eisai by means of AP

Brownstein cited that there are nevertheless questions surrounding the drug's accessibility. the entire approval means Medicare can delivery protecting the can charge of medicine for patients, making it more broadly purchasable, but that is for a subset of patients.

"This drug, like many others, requires sizeable funding for research and development, and so, as a result of that, corporations use drug pricing to recuperate the fees linked to setting up and bringing these medicine to market," he noted. "alas, that pricing, that potential that this drug should be out of attain for some, and that's the reason truly anything that has to be addressed as a result of course, this drug should still be obtainable to any individual affected by this disease."

An mRNA vaccine to treat pancreatic melanoma

A analysis group funded by the countrywide Institutes of fitness (NIH) has developed a customized mRNA vaccine with partners at BioNTech, towards pancreatic cancer, some of the deadliest kinds of melanoma in the U.S.

BioNTech carried out gene sequencing on more samples to determine neoantigens -- proteins which are wonderful to cancer cells – that might also stimulate an immune response.

In early clinical trials, sufferers acquired a drug that inhibits melanoma cells from suppressing the immune system, then were given their personalized vaccine break up in nine doses over many months.

Eighteen of the 19 sufferers correctly had vaccines created for them and 16 had been suit sufficient to acquire at the least one of the vital doses, based on the NIH.

About half of the patients noticed the vaccine trigger T cells, a sort of immune system mobile that destroys infected cells, that focused the certain melanoma cells in each patient.

among the many patients who noticed the mighty immune system response, the cancer did not return after a year and a half of remedy, including chemotherapy. In those that didn't have a robust immune system response, the caner retuned inside a 12 months, based on results posted previous this yr in the journal Nature.

"it be wonderful to peer that a personalized vaccine may enlist the immune gadget to combat pancreatic melanoma—which urgently wants more desirable cures," Dr. Vinod Balachandran, a surgical oncologist from Memorial Sloan Kettering cancer middle, noted in a statement. "it be also motivating as they may well be in a position to use such personalised vaccines to treat other deadly cancers."

AI boosts breast melanoma detection charges

artificial intelligence (AI) has been more and more utilized in scientific trials, and a new device developed this year is assisting spot more breast melanoma than human screenings.

The device, named Mia and developed by Imperial school London and Kheiron scientific applied sciences detected 13% extra early breast cancers.

across the two pilot phases and the live roll out, Mia detected 24 greater cancers and resulted in 70 extra ladies being recalled, according to a unlock from Imperial faculty London.

Of the ladies who have been recalled, extra cancers have been found, which raised melanoma detection quotes through 13%.

"These effects have handed their expectations," Dr Ben Glocker, a professor in computer learning for imaging at ICL, said in an announcement. "These consequences have passed their expectations. Our study suggests that the use of AI can act as an effective safeguard web -- a tool to prevent subtler signs of melanoma falling in the course of the cracks. Seeing firsthand that using AI may significantly cut back the cost of overlooked cancers in breast screening is massive, and a massive increase for their mission to radically change cancer care with AI expertise."


 



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