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Pass4sure HH0-200 Practice Test | Do not miss these Hitachi HH0-200 Questions before test - alphernet.com.au

HH0-200 | Certified Modular Integration Specialist

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HH0-200 - Certified Modular Integration Specialist - braindump

Vendor Hitachi
Exam Number HH0-200
Exam Name Certified Modular Integration Specialist
Questions 109 Q & A
Recent Update January 16, 2019
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HH0-200 exam Dumps Source : Certified Modular Integration Specialist

Test Code : HH0-200
Test Name : Certified Modular Integration Specialist
Vendor Name : Hitachi
Q&A : 109 Real Questions

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Hitachi Hitachi Certified Modular Integration

Hitachi Vantara Strengthens UCP family of Converged and Hyperconverged techniques and purposes Ecosystem options | killexams.com Real Questions and Pass4sure dumps

June 06, 2018 12:00 ET | supply: Hitachi Vantara

SANTA CLARA, Calif., June 06, 2018 (GLOBE NEWSWIRE) -- Hitachi Vantara, a wholly owned subsidiary of Hitachi Ltd. (TSE:6501), nowadays introduced effective hardware and utility enhancements throughout the Hitachi Unified Compute Platform (UCP) family of converged, hyperconverged and rack-scale programs, including NVMe SSD caching and GPU processor-primarily based server alternate options. New certified purposes ecosystem options optimized for mission-important environments encompass SAP HANA®, Oracle databases, VMware and big information analytics frameworks. by means of providing an entire family of UCP converged systems and built-in application options, Hitachi Vantara is in a position to address any workload, at any scale, in multicloud environments.

Hitachi UCP systems give shoppers with simplified, normal platforms that are speedy to install and simple to control, with much less possibility by way of minimizing human error. They enable the agile infrastructure needed to modernize data facilities, allowing purchasers to all of a sudden respond to evolving company wants while effectively managing, governing, mobilizing, conserving and examining statistics to benefit richer insights and power enhanced enterprise effects.

better Hitachi UCP family OfferingsHitachi UCP systems use modular building blocks of infrastructure that are pretested and validated to fulfill certain wants and quick-changing business necessities. They permit valued clientele to birth small and grow methods with increments of low cost compute, network and storage components to optimize efficiency.

Hitachi Unified Compute Platform advisor (UCP guide), the IT management and orchestration software for the Hitachi UCP household, helps full automation over server, network and storage accessories. UCP marketing consultant with custom-made workflows lets IT personnel circulate purposes and workloads between clouds and UCP techniques in a wise and automated option to rapidly carry new IT features. The latest free up of UCP advisor continues to enhance automation, together with coverage-based provisioning to velocity initial deployment with much less chance.

built on a modular converged structure, Hitachi Unified Compute Platform CI (UCP CI) methods deliver a flexible, low-chance route to modern statistics center infrastructure. UCP CI systems with a UCP consultant-powered administration and automation toolset, permit the operational efficiencies of virtualization and raise the efficiency of mission-vital applications. The techniques simplify the handle of each virtual and physical infrastructure to help a wide array of commercial enterprise and cloud workloads, at any scale. 

Enhancements to Hitachi UCP CI techniques encompass help for the recently launched all-flash and hybrid Hitachi digital Storage Platform (VSP) methods. in comparison to prior models, the new VSP techniques give faster, extra efficient performance, containers guide and cross-platform AI-powered analytics and IT automation application. New Intel Skylake-primarily based Hitachi superior Server DS220 and DS240 servers convey multiplied scale-up and scale-out computational alternate options to tackle probably the most disturbing, excessive performance requirements for virtualization, SAP® and Oracle environments.

Hitachi Unified Compute Platform HC (UCP HC) methods are a scalable, effortless-to-set up hyperconverged infrastructure appliance. attainable as an all-inclusive answer, UCP HC leverages VMware vSAN™, the trade-leading software powering hyperconverged infrastructure, for simplicity, agility and utterly-orchestrated setting up, management and improvements. 

the brand new Hitachi advanced Server DS225 with NVIDIA Tesla GPU guide addresses opportunities requiring superior graphics capabilities similar to VDI, CAD/CAE and collaborative offices, together with advanced analytics options. New Intel Optane NVMe SSD caching in the DS120 server offers high performance and low latency transaction processing for essential applications and analytics environments. The better capability storage within the new DS220 server addresses use cases akin to test and development, branch office support, content material repositories and file features.

Hitachi Unified Compute Platform RS (UCP RS) is a rack-scale system designed to simplify the deployment of an agile data infrastructure at scale. When combined with the newest version of VMware’s built-in hybrid cloud platform, VMware Cloud basis, the integrated equipment enables customers to deploy a hybrid cloud with a quick time to market and pay-as-you-go economics. Key new add-ons and enhancements to Hitachi UCP RS include using Intel Skylake all-flash servers for better efficiency and effectivity, and support for VMware vSAN. This lowers the charge for smaller deployments, bringing an easy, comfortable and agile cloud infrastructure to a new category of purchasers.

“we're partnering with Hitachi Vantara to velocity the adoption of hyper-converged infrastructure powered via VMware vSAN to higher businesses”, pointed out Lee Caswell, vp of Product, Storage and Availability enterprise Unit, VMware. “Hitachi Vantara presents exciting integration with VMware solutions, together with VMware vSAN and VMware Cloud foundation, to convey a digital basis for typical and cloud native functions as organisations seek developer-competent infrastructure with a swish new operations model.” 

expanded functions Ecosystem SolutionsApplications ecosystem options, powered by means of the UCP family of systems, carry pre-built-in, optimized and authorized infrastructure options and reference architectures, combined with software-centric skilled capabilities.

the new Hitachi answer for the SAP HANA Platform simplifies the analysis of SAP HANA statistics in addition to large information from varied sources in precise-time to force quickly and more recommended enterprise decisions. New SAP HANA answer options include tailored information middle integration (TDI) certifications with main density and effectivity, scaling to sixty four nodes per body and featuring new Hitachi VSP flash storage systems to run the most disturbing SAP applications. New appliance certifications scale as much as eight CPUs and 12TB and are preferrred for SAP enterprise Suite 4 HANA (SAP S/four HANA®) to power financials, commercial enterprise useful resource planning, give chain management and different mission-crucial enterprise operations. moreover, Hitachi has delivered aid forecasting analytics and threshold alerts to Hitachi Server and Storage Adapters for the SAP HANA Cockpit centralized management console.

A Hitachi answer for Databases with Oracle commercial enterprise facts Warehouse (EDW) optimization offloads heat and bloodless statistics to a data lake along with an authorized MongoDB cluster running on Hitachi UCP RS programs. this can in the reduction of the charge of utility licensing, scale-out capacity and hardware acquisitions while helping analytics on Oracle EDW and MongoDB. Hitachi’s Pentaho statistics Integration allows for entry to each present EDW and secondary massive facts environments from a single device.

Pretested, prevalidated infrastructure featuring certified Cloudera enterprise information Hub and MongoDB commercial enterprise compute clusters, complement Pentaho records Integration for key use instances like cybersecurity. New reference architectures with certified infrastructure for Cloudera and MongoDB deliver purchasers with demonstrated techniques, consistent abilities and most beneficial practices discovered through years of journey in information administration.

“it's important that business customers get the most price from all their records to grow their top line, connect their items and features, and offer protection to their enterprise. together, Hitachi Vantara and Cloudera can help,” said Philippe Marinier, vice chairman, enterprise construction at Cloudera. “the brand new reference architecture from Hitachi Vantara with licensed infrastructure on Cloudera's modern platform for desktop discovering and analytics optimized for the cloud can empower our joint shoppers to transform complex statistics into actionable insights to pressure their digital transformation.”

“Hitachi UCP techniques allow clients to reply sooner to business needs with a simplified, regular platform it truly is quick to deploy and simple to control, with less possibility,” referred to Bob Madaio, vice president, Infrastructure options advertising at Hitachi Vantara. “at the side of greater, pretested software options, Hitachi’s converged infrastructure systems are assisting purchasers be certain highest ROI on the infrastructure working their most important purposes and analytics environments.”

Product Availability and InformationAll new Hitachi UCP techniques and functions ecosystem solutions are both obtainable globally today or are expected to be available in August. Contact a native Hitachi Vantara consultant for selected availability timeframes. For more tips on the Hitachi Unified Compute Platform family, seek advice from: https://www.hitachivantara.com/en-us/products/converged-programs.html.

About Hitachi VantaraHitachi Vantara, a unconditionally owned subsidiary of Hitachi, Ltd., helps data-pushed leaders discover and use the cost in their data to innovate intelligently and reach consequences that count for enterprise and society. We combine technology, highbrow property and business expertise to convey facts-managing options that aid agencies enhance their customers' experiences, increase new salary streams, and decrease the prices of company. most effective Hitachi Vantara elevates your innovation abilities via combining deep counsel technology (IT), operational expertise (OT) and area capabilities. We work with businesses in every single place to power statistics to significant outcomes. consult with us at www.hitachivantara.com.

connect with Hitachi Vantara

About Hitachi, Ltd.Hitachi, Ltd. (TSE:6501), headquartered in Tokyo, Japan, promises improvements that reply society’s challenges, combining its operational expertise, information know-how, and items/systems. The business’s consolidated revenues for fiscal 2017 (ended March 31, 2018) totaled 9,368.6 billion yen ($88.four billion). The Hitachi group is an innovation partner for the IoT period, and it has approximately 307,000 employees worldwide. through collaborative advent with valued clientele, Hitachi is deploying Social Innovation company the usage of digital technologies in a broad latitude of sectors, together with vigour/power, business/Distribution/Water, urban development, and Finance/Social Infrastructure/Healthcare. For greater assistance on Hitachi, please visit the company's website at http://www.hitachi.com.

HITACHI is a trademark or registered trademark of Hitachi, Ltd. VMware, vSAN, and Cloud basis are registered trademarks or logos of VMware, Inc. within the united states and different jurisdictions. All other emblems, service marks, and business names are houses of their respective homeowners.

PRESS CONTACTBrian GarabedianHitachi Vantarabrian.garabedian@hitachivantara.com+1-408-970-7572


Hitachi records techniques declares New Converged and Hyperconverged options for Virtualization and Cloud Environments | killexams.com Real Questions and Pass4sure dumps

most up-to-date members of Hitachi Unified Compute Platform permit companies to start Small, installation promptly and Scale Infrastructure on Their direction to Digital Transformation

SANTA CLARA, CA--(Marketwired - June 21, 2016) - Hitachi information systems, a totally owned subsidiary of Hitachi, Ltd. (TSE: 6501), today introduced Hitachi Unified Compute Platform 2000 (UCP 2000) converged equipment and UCP HC V240, which is the first member of the brand new Hitachi Unified Compute Platform HC (UCP HC) line of hyper-converged solutions. both systems are flexible, agile and scalable for corporations on their digital transformation adventure. developed on confirmed Hitachi technology, these options reduce cost and risk to facts availability whereas assuaging complexity and accelerating time to price.

As digital transformation places facts at the core of business method, converged infrastructures develop into a greater essential element of corporate success. They supply the fastest strategy to set up infrastructure that helps virtualized environments, giving IT leaders the flexibility to manipulate charges, raise provider beginning, meet evolving enterprise expectations and increase income. The Hitachi UCP family unit of converged and hyperconverged infrastructure solutions span from the core of the statistics center to the fringe of the network to fulfill any enterprise IT requirement.

the brand new Hitachi UCP 2000 simplifies and expedites deployment of inner most and hybrid clouds during the birth of a pre-proven, pre-built converged infrastructure platform. With aid for all-flash configurations, the UCP 2000 gives flexibility and scale with modular constructing blocks of compute, storage and networking that scale independently to run different software workloads. Designed and confirmed to guide dissimilar virtualization environments, including VMware as certified hardware within the VMware digital SAN equipped Node program, Microsoft® and OpenStack, UCP 2000 gives a flexible, low-risk path to converged infrastructure and is most suitable for time-honored-aim applications, digital computing device infrastructure (VDI), databases, and examine and building environments. UCP 2000 is a worth-based mostly, entry-level device it really is easy to install and control, and contours tight integration with VMware vRealize and VMware vSphere Storage policy-primarily based administration (SPBM) along with Hitachi records methods statistics coverage applied sciences.

Hitachi UCP HC V240 is an automated, versatile and policy-pushed, hyper-converged infrastructure equipment. The gadget aspects digital desktop (VM) centric swimming pools of capability which are flexibly consumed in response to VM-stage policies that can also be modified on demand. UCP HC V240 supplies high performance and scale with out compromising simplicity and cost-effectiveness. The programs aid consumers construct a groundwork for business purposes and subsequent-technology options with a hyper-converged infrastructure based on Intel x86 hardware and Hitachi information methods cost-brought utility. Hitachi UCP HC V240 is a hyper-converged infrastructure answer this is jointly licensed as a VMware virtual SAN able Node platform and is powered by VMware's market-main Hyper-Converged utility stack.

Designed for simplicity, UCP HC V240 is an all-in-one answer that hastens time to value with swift deployment that allows for purchasers to move from vigor-on to digital desktop introduction in minutes. UCP HC automates provisioning and orchestration, simplifies setting up, administration, patches and improvements, and gives linear scale-out that grows in small increments to satisfy enterprise wants.

"we're seeing expanding demand to deliver built-in methods that are reputable, trusted, and certified can charge-most excellent, from core to part throughout the commercial enterprise," noted Thomas Trela, senior director, options and cloud, Hitachi facts systems. "UCP HC V240 and UCP 2000 programs provide architectural options that may scale compute and storage elements while nevertheless providing simplified management for virtualization specialists."

"we're excited to accomplice with Hitachi in the course of the digital SAN equipped Node program to bring a broad latitude of hyper-converged infrastructure solutions to market. The combination of Hitachi's hardware systems and VMware Hyper-Converged application presents radically primary, least expensive route to digital transformation and helps clients meet ever-changing business needs," stated Fadi Azhari, director of product advertising, VMware.

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About Hitachi statistics methods

Hitachi data programs, a unconditionally owned subsidiary of Hitachi, Ltd., builds information administration and social innovation solutions that assist organizations prevail and societies be safer, healthier and smarter. We focus on big records that presents precise price -- what we call the cyber web of things that matter. Our IT infrastructure, analytics, content material and cloud options and features force strategic administration and evaluation of the world's information. simplest Hitachi data methods integrates the surest tips technology and operational know-how from across the Hitachi household of organizations to bring the notable perception that business and society should radically change and thrive. visit us at HDS.com.

About Hitachi, Ltd.

Hitachi, Ltd. (TSE: 6501), headquartered in Tokyo, Japan, gives you innovations that reply society's challenges. The business's consolidated revenues for fiscal 2015 (ended March 31, 2016) totaled 10,034.3 billion yen ($88.7 billion). The Hitachi group is a worldwide chief within the Social Innovation company, and it has approximately 335,000 employees worldwide. through collaborative creation, Hitachi is proposing options to valued clientele in a vast range of sectors, together with vigor / power, trade / Distribution / Water, city building, and Finance / executive & Public / Healthcare. For more suggestions on Hitachi, please visit the company's web site at http://www.hitachi.com.

HITACHI is a trademark or registered trademark of Hitachi, Ltd. Microsoft is a trademark or registered trademark of Microsoft employer. All different trademarks, service marks, and enterprise names are homes of their respective house owners.


Hitachi Vantara Introduces solutions for Mission-essential SAP HANA, Oracle DB, VMware, and massive data Analytics | killexams.com Real Questions and Pass4sure dumps

Jun 20, 2018

Hitachi Vantara has introduced hardware and software enhancements across the Hitachi Unified Compute Platform (UCP) family of converged, hyperconverged and rack-scale systems, including NVMe SSD caching and GPU processor-primarily based server alternate options.

New certified purposes ecosystem options optimized for mission-vital environments consist of Oracle databases, SAP HANA, VMware, and big information analytics frameworks. via offering a complete family of UCP converged programs and built-in software options, Hitachi Vantara says, it's capable of address any workload, at any scale, in multicloud environments.

Hitachi UCP systems use modular building blocks of infrastructure which are pretested and validated to meet selected wants and speedy-changing business necessities. They permit clients to beginning small and grow programs with increments of least expensive compute, community and storage accessories to optimize performance.

constructed on a modular converged architecture, Hitachi Unified Compute Platform Converged Infrastructure (UCP CI) techniques deliver a flexible, low-chance direction to modern statistics center infrastructure. UCP CI systems, with a UCP consultant-powered administration and automation toolset, permit the operational efficiencies of virtualization and increase the performance of mission-important functions. The techniques simplify the manage of each virtual and actual infrastructure to help a wide array of business and cloud workloads, at any scale. 

Enhancements to Hitachi UCP CI programs encompass support for the these days launched all-flash and hybrid Hitachi digital Storage Platform (VSP) methods. in comparison to prior fashions, the brand new VSP programs provide quicker, extra productive performance, containers aid and move-platform AI-powered analytics and IT automation software.

New Intel Skylake-primarily based Hitachi advanced Server DS220 and DS240 servers deliver accelerated scale-up and scale-out computational alternate options to handle the most stressful, excessive efficiency necessities for virtualization, SAP and Oracle environments.

Hitachi Unified Compute Platform HC (UCP HC) programs are a scalable, handy-to-set up hyperconverged infrastructure appliance. purchasable as an all-inclusive solution, UCP HC leverages VMware vSAN, the application powering hyperconverged infrastructure, for simplicity, agility and entirely-orchestrated setting up, administration and upgrades. 

the new Hitachi advanced Server DS225 with NVIDIA Tesla GPU help addresses alternatives requiring superior images capabilities reminiscent of VDI, CAD/CAE and collaborative places of work, together with advanced analytics solutions. New Intel Optane NVMe SSD caching in the DS120 server gives high efficiency and low latency transaction processing for important purposes and analytics environments. The higher capability storage in the new DS220 server addresses use instances corresponding to test and development, branch office assist, content repositories and file capabilities.

Hitachi Unified Compute Platform RS (UCP RS) is a rack-scale equipment designed to simplify the deployment of an agile statistics infrastructure at scale. When mixed with the latest edition of VMware’s integrated hybrid cloud platform, VMware Cloud basis, the integrated device enables shoppers to install a hybrid cloud with a quick time to market and pay-as-you-go economics. Key new accessories and enhancements to Hitachi UCP RS include using Intel Skylake all-flash servers for better performance and efficiency, and assist for VMware vSAN. This lowers the charge for smaller deployments, bringing a simple, comfy and agile cloud infrastructure to a new classification of valued clientele.

applications ecosystem solutions, powered through the UCP family unit of systems, deliver pre-built-in, optimized and licensed infrastructure solutions and reference architectures, mixed with software-centric expert functions.

the new Hitachi answer for the SAP HANA Platform simplifies the evaluation of SAP HANA information as well as large records from assorted sources in actual-time to drive speedy and more counseled enterprise choices. New SAP HANA solution alternatives encompass tailored records middle integration (TDI) certifications, scaling to 64 nodes per body, and that includes new Hitachi VSP flash storage systems to run the most worrying SAP purposes. New appliance certifications scale as much as eight CPUs and 12TB and are ultimate for SAP enterprise Suite four HANA (SAP S/4 HANA) to power financials, commercial enterprise useful resource planning, supply chain management and different mission-essential business operations. furthermore, Hitachi has added resource forecasting analytics and threshold indicators to Hitachi Server and Storage Adapters for the SAP HANA Cockpit centralized administration console.

A Hitachi solution for Databases with Oracle business statistics Warehouse (EDW) optimization offloads warm and bloodless data to a data lake along with an authorized MongoDB cluster working on Hitachi UCP RS systems. this may in the reduction of the can charge of utility licensing, scale-out ability and hardware acquisitions whereas aiding analytics on Oracle EDW and MongoDB. Hitachi’s Pentaho records Integration permits entry to each latest EDW and secondary big information environments from a single device.

Pretested, prevalidated infrastructure featuring licensed Cloudera business information Hub and MongoDB enterprise compute clusters, complement Pentaho information Integration for key use instances like cybersecurity. New reference architectures with certified infrastructure for Cloudera and MongoDB provide clients with verified programs, consistent abilities and ultimate practices learned through years of journey in facts management.

For extra assistance on the Hitachi Unified Compute Platform family unit, consult with www.hitachivantara.com/en-us/items/converged-methods.html.




Killexams.com HH0-200 Dumps and Real Questions

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HH0-200 exam Dumps Source : Certified Modular Integration Specialist

Test Code : HH0-200
Test Name : Certified Modular Integration Specialist
Vendor Name : Hitachi
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Announcing Apex.AI — We are building an operating system for autonomous vehicles that never fails | killexams.com real questions and Pass4sure dumps

Experts predict that by 2030 at least 15 percent of cars will be fully autonomous. There is no shortage of opinions and hot takes on the latest sensors, use cases, and business models. One topic will be critical for a successful introduction of self-driving cars into market, but it rarely gets as much attention: Reliability, robustness, safety and security of the software that drives the vehicle in lieu of a human driver. Self-driving car software could stall just like laptops stall. A stalled laptop is frustrating but crashed software on a car may have more severe consequences.

Today I am proud to announce Apex.AI. We are focused on creating robust, reliable, safe, and secure software for autonomous mobility systems. Apex.AI is transitioning autonomous vehicle software from R&D to commercialization so that it meets highest safety and reliability standards, a need for both automakers and consumers. We recently closed our $15.5MM Series A funding, led by Canaan with participation from our seed investor Lightspeed.

We believe in a modular and diverse approach to software. Hence, we have designed a modular software stack, that allows for easy integration into existing systems as well as easy integration of 3rd party software. We think highly focused specialists can develop a better overall system than one company developing a full-stack — which will likely not fit all applications. Our software is not designed for peak performance — it’s designed to never fail. We’ve built redundancies into the system design to ensures that single failures don’t lead to system-wide failures.

To understand the problem we’re solving, a brief overview of AV software is helpful.

Background on the current systems

Autonomous vehicles use sensors to perceive objects and other traffic participants. The sensor data feeds into a computer and the computer runs software to understand the environment and to make driving decisions based on this understanding. This software is very complex and contains computer vision, 3D perception, machine learning, localization, decision making, trajectory planning, and control algorithms. These algorithms need a software framework to run in.

ROS, the Robot Operating System developed since 2008, is used by the majority of companies developing applications for autonomous vehicles and by almost all academic labs. ROS is analogous to iOS’s or Android’s SDK in the mobile stack, providing a software framework for developers to build applications on top. ROS has found widespread adoption because it is open source, has a strong community behind it and has seen a decade of application development, and provides a rich ecosystem in addition to the software framework, such as sensor drivers, algorithms, visualization, simulation, build tools and much more. ROS is excellent for rapid prototyping and development but is not designed to run in safety- and security-critical applications. As the industry shifts from development to productization and from testing to real-world applications, the highest level of robustness and reliability is needed.

Apex.AI’s approach to a modular, safe and secure system design

Our first two products are Apex.OS and Apex.Autonomy.

Apex.OS is a robust and reliable software framework or meta-operating system for autonomous mobility. It is an automotive version of ROS 2 and abstracts hardware-specific, real-time, and embedded software development so developers can focus on building production-grade autonomous driving applications on top of Apex.OS. We modify the popular and widely used ROS software framework to ensure compatibility to the development standard and have added mechanisms for real-time, functional safety, and security. Apex.OS will be certified to the highest automotive functional safety level (ASIL D) according to the automotive safety standard ISO 26262 in 2019.

Apex.Autonomy provides developers with building blocks for autonomy. We believe that our customers should be able to pick and choose software building blocks from an ecosystem to compose a software stack that is right for their application — and not take a full-stack that has been developed by a single 3rd party. Instead we have started to build those blocks, e.g. automotive grade LiDAR data processing, and are also partnering to expand this into an open ecosystem.

There are different approaches to building software for autonomous systems and some have chosen to create an entirely new system from scratch. We believe ROS provides significant benefit — including widespread adoption, a huge developer community, and a decade of application development. Apex.OS is meant to transition and bolster ROS, not replace it.

Ultimately, Apex.OS is application agnostic, so any autonomous mobility system — cars, robots, drones, airplanes — can use it.

The Team

Dejan Pangercic, my cofounder and the CTO of Apex.AI, was one of the early contributors to ROS and has worked on software frameworks for over 10 years. I have worked on autonomous vehicle software for over 20 years. We know the people, the technology and the challenges of the autonomous vehicle industry. We’re eager to help solve this problem because it requires deep and innovative technology, application of thorough engineering practices, and a deep understanding of the industry — a task that complements our backgrounds well.

Our people are our secret sauce. Over our 20+ year experience, we’ve seen the power of different perspectives. We think collaboration, openness, and diversity beats individualism. We have assembled an awesome team to tackle the challenge to provide the mobility industry with the safest and most reliable software possible.

Stay tuned.


Aquion Energy, Schneider Electric, and Azimuth Energy Announce AC/DC Hybrid Nanogrid at the Illinois Institute of Technology | killexams.com real questions and Pass4sure dumps

PITTSBURGH, PA--(Marketwired - Sep 12, 2016) - Aquion Energy, Inc., the manufacturer of Aqueous Hybrid Ion (AHI™) batteries and energy storage systems, Schneider Electric, the global specialist in energy management and automation, and Azimuth Energy, a solar-energy and energy-efficiency engineering and construction company, today announced completion of an innovative AC/DC nanogrid at the Illinois Institute of Technology's (IIT) Keating Sports Center. The nanogrid, which was designed and installed by Azimuth Energy, is a combined solar plus energy storage system that uses Aquion Aspen batteries for storage and Schneider power control electronics for energy management.

"This is the future of distributed generation, where isolated loads powered by renewables combined with energy storage can stand alone and operate without the grid," said Tim Poor, chief commercial officer of Aquion Energy. "Our safe and sustainable Aspen batteries are the optimal choice for long-duration storage and deep daily cycling, from nanogrids like this one at IIT to microgrids, island communities, and other nanogrids such as telecom base stations."

The IIT nanogrid is unique because it supports both alternating current (AC) and direct current (DC) loads. During the day, the solar array directly powers the highly efficient DC LED lighting systems and AC loads, while simultaneously charging the batteries. Any excess solar energy can be exported to the grid. In the event of a grid outage, the batteries and solar panels deliver energy to the system 24/7.

"Schneider Electric has always been at the forefront of researching energy management technologies and solutions for microgrids. We were a proud partner in this innovative project, ready to demonstrate the benefits of the flexibility and intelligence of our Conext XW+ family of products. It supports multi-mode operation to create a perfect test-bed for validating a true hybrid system with mixed energy sources and loads on DC and AC distribution," said Xavier Datin, vice president of solar off-grid and residential at Schneider Electric.

"This project will greatly increase energy efficiency, as well as provide critical backup power in case of an outage," said Dr. Mohammad Shahidehpour, Ph.D, IIT's Director of the Robert W. Galvin Center for Electricity Innovation. "In case of emergencies, we will be able to separate the Keating Center from the rest of IIT's grid, while maintaining full power to the facility. We're very pleased with the benefits derived from this project and the innovative technologies that have been implemented."

Although the Keating nanogrid has a connection to the campus microgrid, it is engineered to operate autonomously using only solar and batteries, as an islanded off-grid system. The nanogrid is a demonstration of how a solar plus storage system can provide resilient electricity for critical building loads during power outages, such as police stations and hospitals. In the case of an outage, any building with a nanogrid could continue to be powered by its own sustainable, self-generated electricity. The nanogrid also allows building operators to respond to their power demand and control how and when they use power from the microgrid -- and ultimately from the utility.

"This project was a fun challenge that stretched all our knowledge of microgrids," said Marc Lopata, president of Azimuth Energy. "The Keating nanogrid will provide a reliable and versatile platform for future research by the IIT Galvin Center under the direction of Dr. Shahidehpour. We had less than our expected share of surprises, and I attribute that to the functionality, quality control, and support from Aquion and Schneider."

Aquion's Aspen batteries are clean, sustainable, and long-lasting, can operate at high ambient temperatures, and do not degrade from partial state of charge cycling. Aspen batteries have a unique and environmentally friendly electrochemical design and are the first and only batteries in the world to be Cradle to Cradle Certified™.

The Schneider power electronics that were provided include the Conext XW+ 6848 Hybrid Inverter and the Conext XW MPPT80-600 Charge Controller.

Aquion EnergyAquion Energy is the manufacturer of proprietary Aqueous Hybrid Ion (AHI™) batteries and battery systems for long-duration, stationary energy storage applications. Aquion's Aspen product line is optimized for daily deep cycling for residential solar, green architecture, off-grid and microgrid, telecom towers, energy management, and grid-scale applications. Aquion's high-performance, safe, sustainable, and cost-effective batteries deliver reliability and value for customers. The company's battery systems provide flexible, modular energy storage that enables broad adoption of renewable energy technologies such as wind and solar, reduced reliance on fossil fuels, and optimization of existing grid-tied generation assets.

Schneider ElectricSchneider Electric is the global specialist in energy management and automation. With revenues of ~EUR 27 billion in FY2015, our 160,000+ employees serve customers in over 100 countries, helping them to manage their energy and process in ways that are safe, reliable, efficient and sustainable. From the simplest of switches to complex operational systems, our technology, software and services improve the way our customers manage and automate their operations. Our connected technologies reshape industries, transform cities and enrich lives. At Schneider Electric, we call this Life Is On.

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Digitization of multistep organic synthesis in reactionware for on-demand pharmaceuticals | killexams.com real questions and Pass4sure dumps

A plastic plan for organic synthesis

The infrastructure for chemical synthesis typically lies at either end of a spectrum: small-scale studies in ad hoc assemblies of glassware or large-scale production in capital-intensive custom reactors. Kitson et al. report a hybrid protocol that customizes a blueprint for synthesis of a target compound in a series of interconnected plastic modules, which can be assembled en masse by 3D printing (see the Perspective by Hornung). The approach, demonstrated for the commercial muscle relaxant baclofen, establishes a systematic workflow that is potentially amenable to automation: All that is necessary for synthesis and purification is the introduction of stock solutions and variation of temperature or pressure.

Science, this issue p. 314; see also p. 273

Abstract

Chemical manufacturing is often done at large facilities that require a sizable capital investment and then produce key compounds for a finite period. We present an approach to the manufacturing of fine chemicals and pharmaceuticals in a self-contained plastic reactionware device. The device was designed and constructed by using a chemical to computer-automated design (ChemCAD) approach that enables the translation of traditional bench-scale synthesis into a platform-independent digital code. This in turn guides production of a three-dimensional printed device that encloses the entire synthetic route internally via simple operations. We demonstrate the approach for the γ-aminobutyric acid receptor agonist, (±)-baclofen, establishing a concept that paves the way for the local manufacture of drugs outside of specialist facilities.

The manufacture of active pharmaceutical ingredients (APIs) is vital for modern health care, yet critical drugs are regularly manufactured for a finite period in a limited number of sites. The manufacture of chemical products—whether bulk, fine, or specialty chemicals, such as APIs—is currently based on a model whereby a central plant is exclusively designed for the manufacture of the product, or range of products, sold by that particular company (1). This model holds whether the manufacturer is a large pharmaceutical company or, as is increasingly the case, a contract research organization operating large chemical manufacturing plants to order from the pharmaceutical industry. This process leads to safety issues around both the storage and transport of such materials, as well as the issues inherent in the large-scale manufacture of chemicals (2). In addition, these large-scale plants are often at the mercy of complicated and global supply chains of raw materials, the failure of which at any point will reduce or halt the capacity of the plant to produce materials and deliver them effectively (3, 4). Also, when a given complex intermediate or API goes out of production, the plants are often repurposed and the manufacturing capacity is lost. The reinstatement of the process would require, in the best case, substantial capital investment to reconfigure a chemical plant for its synthesis. To alleviate this issue, we propose a concept whereby the large-scale manufacturing process of complex fine chemicals, such as APIs, is augmented by distributed, point-of-use manufacturing in self-contained cartridges, requiring limited user interaction to produce the desired products on demand. To achieve this, we developed a methodology for the translation of bench-scale synthesis procedures into a step-by-step workflow that could be used to create digital designs for custom reactionware that can be fabricated by using three-dimensional (3D) printing technologies. In this way, we aim to move beyond the preserve of industrial manufacturing and prototyping applications (5), to revolutionize the relationship between the design, manufacture, and operation of functional devices (6–11) and exploit the increasing use of 3D printing in the automation of the chemical sciences (12–15). This methodology, which is in stark contrast to both large- and medium-scale traditional chemical manufacture, and also to the use of continuous-flow and microreactor approaches (1, 16, 17), allows for the distribution of simple chemical precursors and solvents rather than the complex products themselves. These precursors could then continue to benefit from the economies of scale brought by traditional manufacturing processes while complex products with short shelf lives, or lower and more distributed demand, can be produced locally. This has added benefits in terms of manufacture of the final products as the synthesis of smaller quantities is inherently safer than large-scale processes and poses less risk to both operators and infrastructure. Further, the translation of these synthetic approaches into a digitally defined format, where the reactor design and, eventually, an automated synthesis procedure are encoded, could allow the digitization of all chemical products into a very low-cost manufacturing format. This could allow large numbers of discontinued APIs to be made available as they can be brought back into production on a small scale by the fabrication and use of the appropriate cartridges (18, 19).

As a proof of principle, we present a process by which the traditional laboratory-scale synthesis of a commercially available API can be translated into the design of an integrated cartridge. To do this, all the reaction steps and intrasynthesis purification processes are encoded into the 3D architecture of the cartridge so that the chemical reactions, work-ups, and purification are done with minimal user intervention and exposure automatically. We have demonstrated this process in the full synthesis of the anticonvulsant medication (±)-baclofen (see below).

This method for translating traditional laboratory syntheses into a form that can be encapsulated in a single cartridge is split into three layers of consideration, which were iteratively reevaluated during the cartridge development process. The first is the “conceptual layer,” where the chemical reactions and processes necessary are identified and developed. The second is the “digital layer,” in which these processes are translated into digital 3D models of the final cartridge devices. Finally, a “physical layer,” where the digital models are realized as either a modular implementation or a monolithic implementation, is used to generate the finalized cartridge, which can be used to effect the designed synthesis (Fig. 1). These physical systems can then be tested for efficacy as a final implementation, before iterating the process to develop reliable cartridge syntheses.

Fig. 1 Schematic representation of the translation of a multistep synthesis from conception through to implementation as a reaction cartridge.

Reactions necessary for the synthesis are identified (A→B→C→D, top left panel) and the specific chemical and physical processes and reaction parameters necessary for each reaction are laid out (conditions i. – iii., left panel). These processes are then translated into bespoke reaction modules designed to accomplish one or more of the chemical processes identified in the previous step (top right panel). The modules are then designed as 3D CAD models (lower center panel), with libraries of module components to accommodate the required reaction parameters. These digital models can then be fabricated to produce either a modular or monolithic implementation (lower right panel) of the process.

First, the fundamental chemistry required for the transformations is considered and optimized to minimize the necessary interstep purification for the completion of the full synthesis. This approach is similar to that taken to develop telescoped (i.e., consecutive transformations in a single reactor or sequence of reactors without isolation and purification of intermediates) and “one-pot” syntheses (20, 21), often used in process chemistry, both of which aim to maximize the efficiency of the synthetic route. Although here it is not necessary to produce genuinely telescoped syntheses, as modules for interstep purification can be built into the cartridge design, the synthesis of the desired compound, including all reagents and starting materials for all the necessary steps, must be considered as a unified process. The choice of synthetic route to any target compound will be dictated by a number of factors, including the relative availability and cost of starting materials, reagents, and solvents, as well as the compatibility of reaction and purification sequences with the reactor modules produced. In any wide-scale application of our approach, a cost analysis of any proposed synthetic route will have to be performed to ensure its viability for the product. Once the chemistry for the synthesis is developed, a sequence can be produced where the physical processes and reaction parameters—such as heating, cooling, phase separations, reaction volumes, and times—can be identified.

Vital to the success of these modules is the compatibility of the cartridge material with the chemistry being performed. Whereas traditional laboratory syntheses take place mostly in glassware, we use polypropylene (PP) as a basic structural material for the fabrication of the cartridges. We have found that this polyolefinic material, while demonstrating a robust range of chemical compatibility for traditional synthetic organic reactions, is also a suitable substrate for 3D printing applications (22–24). This gives the best balance of chemical resistance and material properties for 3D printing. Therefore, the first step in the design process is testing the reactions necessary for compatibility in the reactor materials. Future iterations of the concept could expand on the materials and fabrication processes available for the reaction modules to further develop the range of chemistries feasible in this system, using, for example, perfluorinated polymers to increase the chemical resistance of the module.

To demonstrate the feasibility of incorporating these PP reactors into the production of APIs, we tested a number of reactions that lead to such targets in test modules fabricated from PP (Fig. 2). We tested reactions for the synthesis of three APIs: the central nervous system inhibitor (±)-baclofen (25), the anticonvulsant lamotrigine (26), and the gastroprotective agent zolimidine (27). As can be seen, all of the reactions tested were observed to work, but with slightly lower efficiency in PP reactors than in traditional glass reactors, owing to physical loss of material on the relatively rough PP surface hampering product recovery. Surface roughness is inherent in the 3D printed process; however, use of other, as yet undeveloped, materials or different manufacturing techniques could reduce this issue. The zolimidine reactions, particularly the copper-catalyzed iodination reaction, experienced a pronounced reduction in efficiency, compared to (±)-baclofen or lamotrigine. We surmised that this was due to side reactions of the iodine with the polypropylene. These issues highlight that the process of translation from glassware must take into account both the physical and chemical properties and limitations of the reactor substrate (23). For this reason, the first two syntheses were selected for further development into reaction cartridges to explore the concept.

Fig. 2 Comparison of glass reactors with plastic reactionware for the optimized synthetic routes to (±)-baclofen (top), lamotrigine (middle), and zolimidine (bottom) with reaction yields for each step (reaction yields in PP vessels given in parentheses).

Single (top right) or double (bottom right) chambered polypropylene reaction test cartridges were used. PP, polypropylene; TBAF, tetrabutylammonium fluoride; THF, tetrahydrofuran.

Once the processes needed for the reaction sequence are identified, the combined continuous protocol is mapped onto the 3D digital designs for the target-specific cartridge. The sequence of processes is split into a series of modules, with each representing a telescoped series of processes that can take place in a single chamber of the 3D printed system. Each process module is then created as a digital model that can be manipulated to provide the correct physical dimensions necessary for the reaction scheme. The 3D models of the cartridges used in this study were created with OpenSCAD software, an open-source framework for CSG (constructive solid geometry) modeling that allows a highly flexible and configurable approach to create versatile libraries of components as reusable pieces of code. Once defined, these pieces of code can be manipulated by the software, allowing the generation of complex reactor geometries with minimal human inputs. For example, in this study, we designed a module library consisting of interchangeable top and bottom components with varying features that can be easily combined to produce reaction vessels with different shapes and features. From a single line of code, an entire module can be created, with 18 different shapes available (i.e., three different tops and six different bottoms can be selected; Fig. 3). The modules were designed around simple chambers where each reaction or process could be performed in as close a manner as possible to the way it would be carried out with traditional batch chemical techniques, easing the transition between published synthesis in glassware and “cartridge” synthesis. Typically, a standard module would have an opening on the top of the wall of the chamber for transfer of reaction mixtures from previous modules and an opening at the bottom of the chamber for expelling material from the module subsequent to the completion of the desired process. The transfer of material between modules is facilitated by a further opening in the roof of the compartment, which can be used to apply pressure that forces the reaction medium out of the chamber via the outlet at the bottom. The opening at the top otherwise equalizes pressure throughout the device to prevent the premature transfer of material, and also allows for application of vacuum to remove and exchange solvents. These modules can then be combined in sequences by use of further components of our module library such as siphon tubes for the transfer of material from one reaction module to another.

Fig. 3 Parameterized approach to the design of individual process modules.

Digital libraries of module components (top) can be easily assembled to produce a wide range of module geometries dictated by the specific process and reaction parameters (e.g., solvent volumes, number of inputs and outputs, etc.) (bottom). Hydrophobic filters for phase separation are shown in red, and fritted glass filters are shown in blue. DCM, dichloromethane. HR, reactor height.

Once a reaction chamber is created, new features can be introduced by subtracting or adding shapes to the module. For example, a filtration device can be made from a module with a top input, a round bottom with a port, and a glass filter. To achieve this feature, a cylindrical model conforming to the dimensions of the physical filter to be inserted is created and subsequently subtracted from the model of a reaction chamber, producing a void space in the model into which the filter fits (see supplementary materials). Phase separation modules were achieved in a similar manner by using hydrophobic frit inserts that effectively separate organic and aqueous phases for product extractions. In keeping with our desire to design synthesis cartridges that can be produced outside traditional manufacturing regimes, we have exploited our group’s development of 3D printed reactors—reactionware—for synthetic chemical applications as a method of prototyping the physical reactors (28, 29). Three-dimensional printing–based fabrication approaches have the added advantage of being intimately linked to the design process.

Fabrication of the modular system was carried out on low-cost (~$2000) 3D printers, Ultimaker 2 and 2+, although many other fused deposition modeling (FDM) printers could print the 3D modules produced through this approach. If it is necessary to incorporate nonprinted materials during 3D printing of the final module, a preprogrammed pause in the printing process is instigated at a point just above the designed void, and the component is inserted in this space before the resumption of printing. Upon completion of printing, the inlet and outlet ports were tapped with a ¼ inch unified national fine (UNF) thread to allow ease of integration with the external infrastructure for performing the reaction sequences. Using standard ports allowed us to attach either standard fluidic tubing connectors such as those found in traditional flow synthesis setups, or widely used Luer lock adapters. These Luer lock connectors are easily reconfigurable, facilitating feedback into the design process.

The API chosen to accomplish a complete end-to-end synthesis was the central nervous system depressant and antispastic medication (±)-baclofen (30, 31) [RS-β-(4-chlorophenyl)-γ-aminobutyric acid] (4) (Fig. 4), a derivative of γ-aminobutyric acid (GABA) that modulates the action of this central inhibitory neurotransmitter (25). This target was chosen as an example to demonstrate that even relatively short syntheses require a disproportionately larger set of chemical processing steps to effect the full synthesis; in the future, we envision that the synthesis of larger numbers of compounds and compound classes will greatly expand the scope of this approach. (±)-Baclofen has found a number of applications since its first reported synthesis and is currently being investigated beyond its traditional use, as a high-dose treatment for alcoholism (32). Many syntheses of (±)-baclofen have been published since it was first reported, often proceeding through the formation, and subsequent hydrolysis, of β-(4-chlorophenyl)-γ-butyrolactam (3). We have modified such a traditional synthesis of (±)-baclofen starting from the commercially available material methyl 4-chloro-cinammate (1), and proceeding via the Michael addition of nitromethane to form 4-nitro-3-(4-chlorophenyl)butanoic acid (2), followed by nickel-catalyzed reductive lactamization and subsequent acid hydrolysis to produce the final product in its commercially available racemic form as a hydrochloride salt. This three–reaction-step sequence contains 12 individual processing steps that must be incorporated into the reactionware device to complete the synthesis (Fig. 4). This sequence was designed to be particularly amenable to translation into the modular or monolithic system as at each stage, the reactions are either sufficiently clean, or reaction impurities that would impinge on subsequent process in the synthesis could be readily removed by phase partition. The final product is purified through a methanol–diethyl ether crystallization, which yields a crystalline solid that can be retrieved directly from the cartridge device. An animation of the entire process, showing the passage of reagents, processes, and work-ups, is shown in movie S1.

Fig. 4 Synthesis of (±)-baclofen in a series reaction cartridges.

(Top) Conceptual synthetic procedure for the synthesis of (±)-baclofen under the conditions described in Fig. 2, showing the necessary processing sequence to effect this synthetic pathway. These processes were then split into modules (a) to (e) (indicated by gray boxes in the process sequences), which we translated into a digital design (middle left) and finally fabricated as either a modular (middle right) or monolithic (bottom left) implementation. A partially fabricated monolithic cartridge is also shown indicating the placement of non-3D printed components and internal fluidic pathways (bottom center and right). Both modular and monolithic cartridges are shown with Luer taper–compatible valving for interfacing with external fluidic inputs and pressure or vacuum lines.

Each of these processes was translated into operations that could be successfully embodied in one or more reaction or purification modules. The specific reaction modules used for the synthesis of (±)-baclofen were (a) a combined Michael addition, evaporation and ether extraction module; (b) a combined solvent exchange and reduction module; (c) a phase separation and filtration module; (d) a combined solvent exchange and hydrolysis module; and (e) a filtration module. Individual modules were fabricated for a “plug-and-play” approach to the reaction process development by using Luer lock fittings to connect individual modules and Luer taper–compatible valves to interface with pressure or vacuum systems. This design allowed testing of each individual process in isolation before the modules were combined to build up the full synthesis. Finally, the module designs were “digitally stitched together” by using the developed CAD libraries for internal fluidic pathways to create the design for a monolithic synthesis cartridge. Once fabricated, the individual modules and the monolithic cartridges were evacuated and filled with a nitrogen atmosphere to ensure an inert environment for the subsequent chemistry.

The first chamber, (a), consists of a lower volume (4.9 ml) where the initial reaction can take place and is separated from the upper outlet by a hydrophobic frit. Reactor modules (b) and (d) consist of a single unbroken reaction chamber (31.8 ml) with sufficient volume to accommodate the reaction volumes and extraction solvents from the previous processes before concentration under reduced pressure. Extraction module (c) consists of a chamber of sufficient volume (4.7 ml) to contain the aqueous phase from the previous chamber, which has a drain at the bottom covered by a hydrophobic frit that prevents both solid material and aqueous solution from passing into the next chamber or module. The final module is a filtration module for separating and retrieving the final product. This single module can be either open to the atmosphere or enclosed as required. During the fabrication process, chambers or modules that required stirring were equipped with a PTFE (polytetrafluoroethylene)–coated magnetic stirring bead (length 10 mm) to enable mixing of the contents. Each module or chamber of the monolith was equipped with a ¼ inch UNF threaded port carrying a female Luer lock adapter, which was used to introduce an inert (dry, N2) atmosphere, or reduced pressure, into the system. The modular system was designed such that there was a single fluidic path through the reactor; flow from one chamber into the next was induced either by pressure from excess solvent, in the case of the phase separation processes, or the introduction of nitrogen pressure difference between the relevant chambers to push the reaction mixture through an embedded channel running from the bottom of one chamber to the top of the next.

Starting materials were prepared as simple solutions and transferred to the cartridge via standard Luer syringes. The cooling and heating required for the reaction sequence were achieved by the immersion of the reaction cartridge or module in an ice or sand bath, respectively, and the temperature required for the reactions can be achieved automatically on a stirring-hotplate. The exact sequence of operations, positioning of the module in the heating or cooling bath, and time intervals necessary for completing the synthesis are outlined in the supplementary materials (figs. S12 and S13 and table S3).

Performing the synthesis starting from 200 mg of 1 in the manner described yielded 98 mg (39% yield over three reaction steps and 12 processing steps from 1 with ≥95% purity as determined by high-performance liquid chromatography) of (±)-baclofen hydrochloride salt, which is more than 1 day’s maximum dosage of the drug. Better efficiency of reaction can be achieved with lower concentrations of starting materials (using a similar cartridge at half concentration, i.e., 100-mg scale, gave a 44% yield over three steps of similar purity). Increasing the volume of the reactor as well increases the quantity of (±)-baclofen obtained [a 300-mg scale synthesis yielded 133 mg (35%) (±)-baclofen]. The integration of the reaction processing steps into the design of the modules greatly simplifies the operations required to perform the reaction sequence compared to traditional bench synthesis and simultaneously reduces the level of technical skills required to perform the process down to simple operations that do not require the specific skills of a trained synthetic chemist. Although the total time for the reaction sequence is around 40 hours in this case, including all intermediate operations, the workflow is constrained by the geometry of the device, so all human interaction is limited to simple interventions at specific time periods, and it should be possible to shorten the interaction time further. The use of such bespoke, single-use cartridges would greatly reduce the time spent on glassware preparation, liquid handling, and other ancillary tasks associated with the majority of chemical syntheses at this scale. Also, by using the geometry of the reactor to constrain the operation of the synthesis, we reduce the human decision making involved in the synthesis processes, making the sequence more reproducible. Given sufficient facilities, several instances of the synthesis cartridge could be used at once, achieving scalability by numbering-up arrays of cartridges, and using these in parallel to increase the output. As a result of the ability to parameterize and encode multistep organic synthesis reactions with work-ups embedded, we envisage that a digital programmable universal heater-stirrer-solvent-reagent plug-and-play device can be constructed into which only the cartridge, specific to a given synthesis, can be plugged in.

The (±)-baclofen synthesis necessitated liquid handling and separation of reaction chambers to effect the full reaction sequence. In some cases, however, syntheses can be conducted in single reaction cartridges, depending on the nature and quality of the interstep purification required. For example, the synthesis of lamotrigine (Fig. 2) can be achieved in a single cartridge as the intermediate material is insoluble in the reaction solvent at low temperatures. In a single, closed, filtration module, the initial reaction product could be washed and processed in situ before introduction of the solvent for the subsequent cyclization step. This stands in contrast to the traditional procedure, which requires the solid product of the first step to be removed from the initial reactor to be filtered, dried, and then reintroduced to a reactor for the second step of the synthesis. Performing the synthesis of lamotrigine on a 250-mg scale of starting material yields 112 mg (46% over two reaction steps) of the final product, giving an off-white crystalline powder.

The digital approach to the design of the system that we have adopted allows the blueprints for these cartridges to be stored electronically for implementation as and when required. The distribution model for fine and specialty chemicals, such as the APIs implied by this approach, would lead to a decentralizing of logistical approaches to chemical manufacture. Here, any location with access to a sufficiently diverse market of chemical precursors and suitable cartridge fabrication facilities could be used to produce chemical products, which could previously be achieved only in a fully equipped synthesis laboratory with highly trained staff. This approach not only holds promise for eventually delivering on-demand personalized medicines manufactured at, or near, the point of use, but also has short-term potential applications in the synthesis of APIs that are currently out of production. An immediate impact of digitization is that the cost for synthesis at the bench scale (milligrams) could decrease markedly owing to savings in labor and infrastructure with only a one-off digitization cost (and allow operators to make 5 to 10 different products at the same time). Once the saving meets the digitization cost, the efforts of the expert chemist will shift from bespoke on-demand chemical manufacturing to chemical digitization (see supplementary materials for an economic analysis). Our methodology will have the most rapid impact for chemicals that are currently produced on demand in small batches and that occupy a gap in the market where the demand for a product is sufficient for it to be commercially viable but insufficient to justify plant-scale production. This gap lies between the high cost of bench-scale versus reactor-scale synthesis, and thus the digitization benefit of compounds in this zone is high.

The regulatory framework necessary to produce complex materials in this fashion will need thorough attention; indeed, our approach would require a completely new system for the regulation of API manufacture. This system would have to be developed alongside the evolution of this approach as a method for pharmaceutical synthesis, which we have presented here in proof-of-concept form; however, we can envision a situation in which regulatory agencies certify specific cartridge or module designs as soon as a digitized process is fully established (including the embedded quality-control protocols), independent of the physical location of person who uses the cartridge. This approach has multiple benefits. First, the framework can adopt well-established methods of digital object certification from the information technology universe (e.g., digital signing with asymmetric ciphers). Second, no explicit certification would be needed for each new “facility” (which might be a hospital or a private house) that would need the drug. Third, existing methods for protecting and manipulating digital content provide much more efficient models for distribution and regulation compared to the retail and patent system, respectively. These regulatory issues surrounding the commercial or clinical application of this approach are not trivial, and care must be taken to ensure that end-user safety is not compromised. However, we believe that the benefits in terms of efficiency of delivery, robustness of supply, and range of materials available could lead to the digitization of chemical synthesis.

Acknowledgments: We acknowledge the help of S. Marshall in compiling our analysis of the economic impact of our methodology. Supplementary materials include a PDF document detailing the materials and methods used in this article; the STL and OpenSCAD files used to generate all 3D printed objects mentioned; a schematic movie illustrating the process of baclofen synthesis in the monolithic cartridge; and Python code that can be used to automate the stirrer-hotplate operations for the baclofen synthesis. We gratefully acknowledge financial support from the Engineering and Physical Sciences Research Council (grant nos. EP/H024107/1, EP/J015156/1, EP/K021966/1, EP/L015668/1, EP/L023652/1) and European Research Council (project 670467 SMART-POM). This research was developed with funding from the Defense Advanced Research Projects Agency (DARPA). The views, opinions and/or findings expressed are those of the author and should not be interpreted as representing the official views or policies of the Department of Defense or the U.S. Government. L.C. is the founder and director of CroninGroupPLC and is listed as an inventor on a patent application filed by The University of Glasgow (GB 1800299.8). L.C. conceived the initial concept and the design approach; P.J.K. designed the reactionware with help from J.P.F. and S.Z.; G.M. and R.C.S. telescoped the methods, porting them from glass to plastic; and P.J.K. developed the monolithic cartridges with help from S.Z. J.S.M. helped evaluate the purity of the products, and P.J.K. coordinated the team with help from L.C.



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