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650-331 | SP Video Phase II Wireline

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650-331 - SP Video Phase II Wireline - braindump

Vendor Cisco
Exam Number 650-331
Exam Name SP Video Phase II Wireline
Questions 20 Q & A
Recent Update February 14, 2019
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650-331 exam Dumps Source : SP Video Phase II Wireline

Test Code : 650-331
Test Name : SP Video Phase II Wireline
Vendor Name : Cisco
Q&A : 20 Real Questions

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Cisco SP Video Phase II

Evolution of Key Cisco leadership Positions | killexams.com Real Questions and Pass4sure dumps

Cisco’s long-standing belief has all the time been that organizations need to evolve to power forward and lead through market transitions.  The same is correct for our government skill.  Evolving our skill requires putting them in new roles, increasing their viewpoint and skill units and bringing clean concepts and energy to the enterprise. here's what we’ve recently done with Edzard Overbeek’s new move from SVP of our Asia-Pacific-Japan area to move of our international features enterprise and Bruce Klein’s stream from SVP of Public Sector income to the head of our global associate firm.

during the last 12 months, we have refocused our engineering corporation for agility, better determination making, and a renewed focus on innovation.  The market share numbers speak for themselves and our customer self assurance has never been more suitable.  we've a strong management group and the company community leaders have established strong execution.  Now the time is appropriate for us to drive the next phase of our organizational evolution.

With that, we're glad to announce Padmasree Warrior will extend her position to turn into Cisco’s Chief expertise and strategy Officer where she might be liable for identifying customer and business transitions and determining Cisco’s method to handle them.  Padma will work carefully with Cisco’s engineering, box, operations and functions leadership, and should outline method, investments, acquisitions and the evolution of Cisco’s technology associate ecosystem.   moreover, Padma can be responsible for concept management around Cisco’s products and architectures, technical talent construction and recruiting, and he or she will increase her time with exterior stakeholders.  The enterprise neighborhood CTO’s will document dotted line to Padma to permit mighty alignment between expertise method, enterprise method and M&A pastime.  over the last 4 years, Padma has dependent a massive track record of consequences, corresponding to constructing Cisco’s approach and execution around architectures, cloud, general expertise method framework, and attracting and constructing industry leading technical talent.  We seem to be forward to accelerating our market position under Padma’s strategic course.

After 13 years of amazing carrier to Cisco, Ned Hooper could be leaving the immediate Cisco household to kind an unbiased investment partnership company and to pursue his goal to be a most important investor.  Ned has been working on his plan with us over a number of months, and we seem forward to partnering with him in his new pastime.  Ned has a unique ardour and ability for funding and method, and should focal point on this within the subsequent part of his profession.   Ned pioneered the model for significant-scale M&A at Cisco and drove gigantic transactions for the business corresponding to Tandberg, WebEx, Airespace, Starent and NDS.  moreover, he has managed our $2B funding portfolio with each strategic and fiscal returns to the business. Ned’s approach and business building crew will now report to Padma.  we would want to thank Ned for his contributions, management, friendship and his continual drive to at all times do the correct element for Cisco.

at last, Pankaj Patel will expect the management of Cisco’s engineering corporation.  Pankaj will pressure innovation, operational excellence and agile construction throughout our products, options and architectures, and continue to raise our relevance with our increasing client base.  Pankaj’s deep client relationships and wide engineering capabilities, combined together with his capability to mentor and grow right engineering ability will serve Cisco well as we power the subsequent section of engineering leadership for the business.  when you could be time-honored with Pankaj’s provider issuer event, he previously spent sixteen years within the commercial enterprise area.  during the last 13 years, Pankaj developed and grew Cisco’s provider issuer company which today debts for approximately 35% of Cisco’s direct product profits. Pankaj’s management in key provider issuer areas reminiscent of core routing, aspect routing, SP mobility and SP video has placed Cisco extremely smartly for the future. right through his tenure Pankaj has delivered a major number of items to the Cisco portfolio, addressing a wide range of client needs.  over the last yr as the co-leader of engineering, Pankaj has multiplied his involvement in Cisco’s business company, as the intersection points between service provider and enterprise come nearer together.

As we live focused on being the most effective Cisco for our customers, companions, traders and employees nowadays, we not ever lose music of the place we are looking to go in the future.  we are enthusiastic about this evolution in our company. Please join us in congratulating Padma, Pankaj and Ned on the next section of their respective journeys.

John Chambers and Gary Moore

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Cisco methods (CSCO) John T. Chambers on Q3 2015 results - salary call Transcript | killexams.com Real Questions and Pass4sure dumps

No effect found, are attempting new key phrase!SP video ... Cisco's management in the web of everything. Now let me give an replace on Cisco's momentum in cloud. We proceed to guide within the hybrid cloud market and raise our intercloud mother...

Chief Minister Edappadi ok Palaniswami inaugurates 13 parks within the Chennai | killexams.com Real Questions and Pass4sure dumps

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CHENNAI : Chief Minister Edappadi ok Palaniswami inaugurated 13 new parks in numerous constituents of Chennai on Monday, and commissioned the underground sewerage amenities, built at a cost of 35 crore at Soorpattu in Madhavaram zone anyway equivalent underground sewerage facilities at Puthagaram and Kathirvedu at a total can charge of Rs.60 crore, in the course of the video conferencing facility on the Secretariat.  the executive minister commissioned and inaugurated numerous works completed at a total charge of 103.40 crores. 

The 13 parks are located at Ramachandra highway in Santhosh Nagar (Mugalivakkam), Tsunami Quarters (AIR Nagar) in Ennore, Balakrishna Nagar, Vegetarian Village (Puzhal), Puthagaram, Padmavathi Nagar carrier highway, Padmavathi Nagar in Kathirvedu, Seventh street, Ponniammanmedu and Thanikachalam Nagar, VIP Nagar in Mogappair, Veermamunivar street, Annai Velankanni Nagar section-II (Mugalivakkam) and Rajiv Gandhi road (Sollinganallur). 

the executive minister additionally inaugurated babies’s playgrounds at TVS Colony forty fifth highway and Officers Colony in Ambattur zone and workplace structures for Municipal administration branch. Municipal Administration Minister SP Velumani, Rural Industries Minister P Benjamin, Chennai service provider Commissioner D Karthikeyan and senior officials had been existing on the event.


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ASCO GU 2019: Results of a 50 Patient Single-Centre Phase II Prospective Trial of Lutetium-177 PSMA-617 Theranostics in mCRPC | killexams.com real questions and Pass4sure dumps

San Francisco, CA (UroToday.com) PSMA is over-expressed in all prostate tissue, including prostatic carcinoma. Lutetium-177 (177Lu)-PSMA617 (LuPSMA) is a small radiolabeled molecule which binds to PSMA and delivers a dose of β radiation. Lutetium-177 is a good partner to help deliver the radiation because of the short range β radiation (maximal tissue penetration of <2mm), thereby decreasing the potential collateral damage to nearby organs. 

The authors of this study have previously reported on their experience of 30 men with metastatic CRPC treated in a single-center phase II prospective trial of LuPSMA.1 This abstract represents an updated analysis of an extended cohort of 50 patients.  

In this phase II trial, 50 men with PSMA-avid (defined as high PSMA expression in at least one site of metastatic disease with > 1.5 SUV of the liver) mCRPC who had progressed after standard therapies (including docetaxel and androgen-axis targeted therapies) received up to 4 cycles of LuPSMA every 6 weeks. The full protocol can be seen below: ResultsSchema_177LuPSMA.png

The primary endpoints were PSA response (according to PCWG2 criteria) and toxicity (according to CTCAE v4). Secondary endpoints included imaging response, PSA PFS and OS. 

75 men were screened to identify 50 patients eligible for treatment. Median PSA doubling time was 2.6 months. The majority of patients had received prior docetaxel (84%), cabazitaxel (48%), and abiraterone and/or enzalutamide (90%). Full demographic info is seen below:PatientDemographicInfo.png

These men are heavily pretreated mCRPC patients with limited alternative options. The mean administered radioactivity was 7.5 GBq/cycle.  

In terms of response, PSA decline ≥ 50% was achieved in 32 of 50 patients (64%, 95% CI 50-77%), including 22 patients (44%, 95% CI 30-59%) with a PSA decline ≥ 80%. Best PSA response is depicted here: BestPSAResponse_ASCOGU.png

27 patients had measurable soft tissue at baseline and 56% of these patients had a partial or complete response by RECIST 1.1 criteria.  

Median PSA PFS was 6.9 months (95% CI 6.0-8.7) and median OS was 13.3 months (95% CI 10.5-18.0). Upon subsequent progression, further LuPSMA was administered to 14 patients (median 2 cycles commencing 359 days from enrolment); PSA ≥ 50% response occurred in 9 patients (64%), indicating the option for retreatment. 

The PFS KM curve:PFS_KM_Curve.pngPatients who had a >= 50% response had a PFS of 8.3 months. 

OS K-M curve seen below:OS_KM_Curve.pngMen who had a >= 50% PSA response had a median OS of 18 months.  

Overall, LuPSMA was well tolerated. The most common toxicities attributed to LuPSMA were transient G1-2 dry mouth in 68%, G1-2 nausea in 48%, and G1-2 fatigue in 36%. G3-4 toxicities attributed to LuPSMA were infrequent with thrombocytopenia in 10% and anemia in 10%.  

Using this expanded 50 patient cohort confirms high response rates and low toxicity with LuPSMA in men who had progressed after standard therapies. In patients who subsequently progressed and were administered further LuPSMA, high response rates were also observed, indicating that this treatment can be repeated with significant response. These results have provided the basis for randomized controlled trials currently underway – the ANZUP/PCFA TheraP trial (Lutetium-PSMA vs. cabazitaxel) and the Endocyte VISION trial.  

Presented By: Michael Hofman, FRACP, MBBS, nuclear medicine physician in the Centre for Cancer Imaging at the Peter MacCallum Cancer in Melbourne

Written by: Thenappan Chandrasekar, MD, Clinical Instructor, Thomas Jefferson University; Twitter: @tchandra_uromd, @JEFFUrology at the 2019 American Society of Clinical Oncology Genitourinary Cancers Symposium, (ASCO GU) #GU19, February 14-16, 2019 - San Francisco, CA

References: 

  • Hofman MS, Violet J, Hicks RJ, Ferdinandus J, Thang SP, Akhurst T, Iravani A, Kong G, Ravi Kumar A, Murphy DG, Eu P, Jackson P, Scalzo M, Williams SG, Sandhu S. [177Lu]-PSMA-617 radionuclide treatment in patients with metastatic castration-resistant prostate cancer (LuPSMA trial): a single-centre, single-arm, phase 2 study. Lancet Oncol. 2018 Jun;19(6):825-833. doi: 10.1016/S1470-2045(18)30198-0. Epub 2018 May 8. 

  • FCC's $2B CAF Auction to Strengthen Network in Rural U.S. | killexams.com real questions and Pass4sure dumps

    Leading wireline and wireless service providers that are interested in extending their reach in rural United States with high-speed broadband services will get a chance to bid for an additional $2 billion in government’s Connect America Fund II (CAFII) subsidy.

    In 2015, the Federal Communications Commission had (FCC) offered more than $10 billion over the next six years in CAFII subsidy to deploy high-speed Internet connections through rural United States.  In May 2016, the FCC had approved a reverse auction to provide an additional $2 billion in funds to rural broadband providers through its CAF II program in an effort to accelerate growth.

    The FCC will adopt four technology neutral service standards: (1) delivering 10/1 Mbps speed (2) delivering 25/3 Mbps and offering a usage allowance of 150 GB a month (3) meeting an above baseline tier that requires bidders to provide 100/20 Mbps and (4) an unlimited monthly usage allowance and meeting a Gigabit performance tier that requires bidders to provide at least 1 Gbps downstream and 500 Mbps upstream and offer an unlimited monthly usage allowance.

    In 2015, several large wireline operators including AT&T Inc. T, CenturyLink Inc. CTL, Frontier Communications Corp. FTR and Windstream Holdings Inc. WIN accepted $9 billion over a period of six years from Phase II of the Connect America Fund to expand broadband in their rural service areas. Later in March 2016, the FCC reformed its broadband support for the nation's smallest carriers, providing $20 billion over the next decade.

    CenturyLink carries a Zacks Rank #5 (Strong Sell) while AT&T, Frontier and Windstream carry a Zacks Rank #3 (Hold). You can see the complete list of today’s Zacks #1 Rank (Strong Buy) stocks here.

    Double-Edged Sword of Trump

    President Donald Trump’s proposed policy changes have made the overall economic outlook fairly bullish. The two pro-growth agendas of Trump, namely, significant cut in corporate tax and deregulation are major catalysts to the U.S. economy.  The proposal to reduce corporate taxes from their current 35% to 20% is likely to bring corporate tax rate at its historic low in 78 years. The tax proposal is likely to provide incentives to companies to repatriate accumulated profits from overseas with an even lower tax rate.

    Additionally, Trump has stated that he wants to do away with nearly 75% of all governmental regulations during his term as President. Major proposals like a pledge to spend $1 trillion in infrastructure projects over a period of 10 years coupled with the above-mentioned policy changes are likely to spur higher consumer spending that may create about 25 million new jobs over a decade. This in turn will fuel long-term economic growth.

    Bottom Line

    The telecommunications industry is witnessing rapid technological improvement. A growing economy speeds up the demand for real-time voice, data, and video manifold. The escalation in demand for telecom services in the rural areas has encouraged telecom service providers to undertake large network extensions while upgrading plans.

    Zacks Editor-in-Chief Goes "All In" on This Stock

    Full disclosure, Kevin Matras now has more of his own money in one particular stock than in any other. He believes in its short-term profit potential and also in its prospects to more than double by 2019. Today he reveals and explains his surprising move in a new Special Report.

    Download it free >>

    Want the latest recommendations from Zacks Investment Research? Today, you can download 7 Best Stocks for the Next 30 Days. Click to get this free report AT&T Inc. (T) : Free Stock Analysis Report CenturyLink, Inc. (CTL) : Free Stock Analysis Report Windstream Holdings, Inc. (WIN) : Free Stock Analysis Report Frontier Communications Corporation (FTR) : Free Stock Analysis Report To read this article on Zacks.com click here. Zacks Investment Research


    Puma Biotechnology, Inc. (PBYI) CEO Alan Auerbach on Q2 2018 Results - Earnings Call Transcript | killexams.com real questions and Pass4sure dumps

    No result found, try new keyword!In addition, we expect to report additional data from our Phase II CONTROL study involving the use of antidiarrheal ... physicians and also as you know there is a lot of these online videos that physi...


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