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117-303 | LPI Level 3 303

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117-303 - LPI Level 3 303 - braindump

Vendor LPI
Exam Number 117-303
Exam Name LPI Level 3 303
Questions 101 Q & A
Recent Update February 12, 2019
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117-303 exam Dumps Source : LPI Level 3 303

Test Code : 117-303
Test Name : LPI Level 3 303
Vendor Name : LPI
Q&A : 101 Real Questions

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LPI LPI Level 3 303

Laredo Petroleum (LPI) earnings anticipated to grow: if you happen to buy? | killexams.com Real Questions and Pass4sure dumps

Wall road expects a yr-over-12 months increase in earnings on higher revenues when Laredo Petroleum (LPI) stories consequences for the quarter ended December 2018. while this largely-popular consensus outlook is critical in gauging the enterprise's income photo, a powerful aspect that may influence its near-term stock fee is how the precise effects compare to these estimates.

The inventory may circulation larger if these key numbers correct expectations within the upcoming earnings document, which is expected to be released on February 13. on the other hand, in the event that they miss, the stock may additionally circulation lessen.

whereas management's discussion of enterprise circumstances on the revenue name will in most cases assess the sustainability of the instant expense change and future revenue expectations, it be price having a handicapping perception into the percentages of a favorable EPS surprise.

Zacks Consensus Estimate

This oil and natural gasoline business is anticipated to submit quarterly income of $0.20 per share in its upcoming document, which represents a 12 months-over-12 months alternate of +5.3%.

Revenues are anticipated to be $242.59 million, up 0.9% from the year-ago quarter.

Estimate Revisions style

The consensus EPS estimate for the quarter has been revised 44.44% reduce over the final 30 days to the latest stage. this is just about a mirrored image of how the protecting analysts have collectively reassessed their preliminary estimates over this length.

investors should still take into account that an combination exchange may additionally not all the time mirror the course of estimate revisions via every of the protecting analysts.

expense, Consensus and EPS shock

revenue Whisper

Estimate revisions ahead of an organization's profits unlock offer clues to the company situations for the duration whose consequences are coming out. This perception is at the core of our proprietary shock prediction mannequin -- the Zacks salary ESP (expected shock Prediction).

The Zacks revenue ESP compares probably the most correct Estimate to the Zacks Consensus Estimate for the quarter; probably the most correct Estimate is a more contemporary version of the Zacks Consensus EPS estimate. The thought here is that analysts revising their estimates appropriate earlier than an revenue liberate have the newest assistance, which might probably be greater accurate than what they and others contributing to the consensus had anticipated earlier.

accordingly, a good or negative salary ESP studying theoretically indicates the likely deviation of the genuine revenue from the consensus estimate. although, the mannequin's predictive vigor is tremendous for tremendous ESP readings most effective.

a positive earnings ESP is a robust predictor of an salary beat, specifically when combined with a Zacks Rank #1 (potent purchase), 2 (buy) or 3 (cling). Our research indicates that stocks with this combination produce a good shock essentially 70% of the time, and an excellent Zacks Rank really increases the predictive energy of profits ESP.

Please word that a negative earnings ESP studying is not indicative of an profits omit. Our analysis suggests that it's problematic to foretell an salary beat with any degree of confidence for shares with bad salary ESP readings and/or Zacks Rank of 4 (promote) or 5 (strong sell).

How Have the Numbers shaped Up for Laredo Petroleum?

For Laredo Petroleum, the most accurate Estimate is the same because the Zacks Consensus Estimate, suggesting that there are no contemporary analyst views which differ from what have been considered to derive the consensus estimate. This has resulted in an profits ESP of 0%.

Story continues

nonetheless, the stock at present includes a Zacks Rank of #3.

So, this mixture makes it complicated to conclusively predict that Laredo Petroleum will beat the consensus EPS estimate.

Does revenue surprise history hang Any Clue?

Analysts often agree with to what extent a company has been in a position to in shape consensus estimates during the past while calculating their estimates for its future salary. So, it's price taking a look at the shock historical past for gauging its have an effect on on the upcoming number.

For the last pronounced quarter, it turned into anticipated that Laredo Petroleum would submit revenue of $0.30 per share when it in fact produced income of $0.27, providing a surprise of -10%.

Over the final four quarters, the company has crushed consensus EPS estimates just once.

bottom line

An earnings beat or leave out may additionally not be the only real groundwork for a stock relocating higher or lower. Many shares become losing floor regardless of an profits beat due to different components that disappoint buyers. in a similar way, unexpected catalysts aid a couple of shares gain despite an earnings miss.

That mentioned, having a bet on stocks which are anticipated to beat revenue expectations does raise the chances of success. here is why or not it's price checking a corporation's earnings ESP and Zacks Rank ahead of its quarterly free up. make sure to utilize our earnings ESP Filter to uncover the most reliable stocks to buy or sell earlier than they've suggested.

Laredo Petroleum does not appear a compelling income-beat candidate. although, traders should pay attention to other elements too for betting on this inventory or staying faraway from it forward of its earnings release.

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largest Movers in power shares Now – EPE TOO LPI NE | killexams.com Real Questions and Pass4sure dumps

energy stocks rose 2.6% on Wall highway these days.

more extensively, the Dow Jones Industrial general declined 0.1%, the Nasdaq stayed level and the S&P 500 was down 0.1%.

one of the greatest gainers amongst energy stocks encompass:

  • Ep power Corp (EPE): EPE stock is up 12.7%, marking the fourth consecutive day the inventory has multiplied.
  • Teekay Offshore companions L.P. (TOO): TOO inventory is up 12.3%, marking the third consecutive day the inventory has increased.
  • Laredo Petroleum Holdings Inc (LPI): LPI stock is up 12.0%, marking the third consecutive day the stock has expanded.
  • Noble Corp (NE): NE stock is up 9.5%, marking the third consecutive day the stock has elevated.
  • Stone energy Corp (SGY): SGY stock is up 8.7% today and up 21.9% within the ultimate month.
  • Synergy materials Cp (SYRG): SYRG stock is up eight.5% nowadays and up 37.9% in the final month.
  • Cobalt international energy (CIE): CIE stock is up 7.7%, marking the third consecutive day the stock has elevated.
  • Whiting Petroleum Corp (WLL): WLL inventory is up 7.5%, marking the third consecutive day the stock has increased.
  • Pengrowth energy Corp (PGH): PGH inventory is up 7.2% these days and up 26.6% in the last month.
  • Atwood Oceanics (ATW): ATW inventory is up 7.1%, marking the third consecutive day the stock has increased.
  • probably the most largest losers among power stocks include:

  • Calumet strong point items (CLMT): CLMT stock is down 1.5% these days.
  • Tesoro Logistics LP common Unit (TLLP): TLLP stock is down 1.eight% these days on four instances common volume.
  • herbal aid companions LP (NRP): NRP stock is down 1.6% today.
  • Atlas Pipeline companions L.P. (APL): APL stock is down 1.5% these days on 2 instances standard extent.
  • Buckeye companions L.P. (BPL): BPL inventory is down 1.4% these days.
  • Enbridge energy administration Llc (EEQ): EEQ stock is down 1.1% today.
  • Suburban Propane companions L.P. (SPH): SPH stock is down 0.9% today.
  • Ypf Sociedad Anonima (YPF): YPF inventory is down 0.6% these days and down 21.5% within the closing month.
  • World gasoline services Corp (INT): INT stock is down 0.5% nowadays on 3 instances common volume.
  • Compagnie Generale De Gephysqu (CGG): CGG inventory is down 0.4% nowadays and down 32.3% in the ultimate month.
  • For extra suggestions on the most beneficial shares to buy presently, check out the newest commentary on InvestorPlace.com.

    And for extra on the sizzling shares relocating most on Wall highway presently, take a look at our archive of each day market movers with the aid of sector right here.

    Editor’s be aware: Returns for the fastest-moving stocks listed here are in line with share expenditures 20 minutes earlier than e-book of this story.


    Laredo Petroleum (LPI) Q3 2018 outcomes - revenue call Transcript | killexams.com Real Questions and Pass4sure dumps

    No outcomes found, try new keyword!Laredo Petroleum, Inc. (NYSE:LPI) Q3 2018 salary name November 6 ... that we are going to seek advice from all through the call this morning. As that you would be able to see on slide 3, Laredo's historical past of enhancing operational effici...

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    Laredo Petroleum (LPI) Earnings Expected to Grow: Should You Buy? | killexams.com real questions and Pass4sure dumps

    Wall Street expects a year-over-year increase in earnings on higher revenues when Laredo Petroleum (LPI) reports results for the quarter ended December 2018. While this widely-known consensus outlook is important in gauging the company's earnings picture, a powerful factor that could impact its near-term stock price is how the actual results compare to these estimates.

    The stock might move higher if these key numbers top expectations in the upcoming earnings report, which is expected to be released on February 13. On the other hand, if they miss, the stock may move lower.

    While management's discussion of business conditions on the earnings call will mostly determine the sustainability of the immediate price change and future earnings expectations, it's worth having a handicapping insight into the odds of a positive EPS surprise.

    Zacks Consensus Estimate

    This oil and natural gas company is expected to post quarterly earnings of $0.20 per share in its upcoming report, which represents a year-over-year change of +5.3%.

    Revenues are expected to be $242.59 million, up 0.9% from the year-ago quarter.

    Estimate Revisions Trend

    The consensus EPS estimate for the quarter has been revised 44.44% lower over the last 30 days to the current level. This is essentially a reflection of how the covering analysts have collectively reassessed their initial estimates over this period.

    Investors should keep in mind that an aggregate change may not always reflect the direction of estimate revisions by each of the covering analysts.

    Price, Consensus and EPS Surprise

    Earnings Whisper

    Estimate revisions ahead of a company's earnings release offer clues to the business conditions for the period whose results are coming out. This insight is at the core of our proprietary surprise prediction model -- the Zacks Earnings ESP (Expected Surprise Prediction).

    The Zacks Earnings ESP compares the Most Accurate Estimate to the Zacks Consensus Estimate for the quarter; the Most Accurate Estimate is a more recent version of the Zacks Consensus EPS estimate. The idea here is that analysts revising their estimates right before an earnings release have the latest information, which could potentially be more accurate than what they and others contributing to the consensus had predicted earlier.

    Thus, a positive or negative Earnings ESP reading theoretically indicates the likely deviation of the actual earnings from the consensus estimate. However, the model's predictive power is significant for positive ESP readings only.

    A positive Earnings ESP is a strong predictor of an earnings beat, particularly when combined with a Zacks Rank #1 (Strong Buy), 2 (Buy) or 3 (Hold). Our research shows that stocks with this combination produce a positive surprise nearly 70% of the time, and a solid Zacks Rank actually increases the predictive power of Earnings ESP.

    Please note that a negative Earnings ESP reading is not indicative of an earnings miss. Our research shows that it is difficult to predict an earnings beat with any degree of confidence for stocks with negative Earnings ESP readings and/or Zacks Rank of 4 (Sell) or 5 (Strong Sell).

    How Have the Numbers Shaped Up for Laredo Petroleum?

    For Laredo Petroleum, the Most Accurate Estimate is the same as the Zacks Consensus Estimate, suggesting that there are no recent analyst views which differ from what have been considered to derive the consensus estimate. This has resulted in an Earnings ESP of 0%.

    Story continues

    On the other hand, the stock currently carries a Zacks Rank of #3.

    So, this combination makes it difficult to conclusively predict that Laredo Petroleum will beat the consensus EPS estimate.

    Does Earnings Surprise History Hold Any Clue?

    Analysts often consider to what extent a company has been able to match consensus estimates in the past while calculating their estimates for its future earnings. So, it's worth taking a look at the surprise history for gauging its influence on the upcoming number.

    For the last reported quarter, it was expected that Laredo Petroleum would post earnings of $0.30 per share when it actually produced earnings of $0.27, delivering a surprise of -10%.

    Over the last four quarters, the company has beaten consensus EPS estimates just once.

    Bottom Line

    An earnings beat or miss may not be the sole basis for a stock moving higher or lower. Many stocks end up losing ground despite an earnings beat due to other factors that disappoint investors. Similarly, unforeseen catalysts help a number of stocks gain despite an earnings miss.

    That said, betting on stocks that are expected to beat earnings expectations does increase the odds of success. This is why it's worth checking a company's Earnings ESP and Zacks Rank ahead of its quarterly release. Make sure to utilize our Earnings ESP Filter to uncover the best stocks to buy or sell before they've reported.

    Laredo Petroleum doesn't appear a compelling earnings-beat candidate. However, investors should pay attention to other factors too for betting on this stock or staying away from it ahead of its earnings release.

    Want the latest recommendations from Zacks Investment Research? Today, you can download 7 Best Stocks for the Next 30 Days. Click to get this free report To read this article on Zacks.com click here.


    Piwi-like 1 protein expression is a prognostic factor for renal cell carcinoma patients | killexams.com real questions and Pass4sure dumps

    Piwl-like 1 expression and correlation with clinico-pathological parameters Cohort 1

    In the cohort 1 (N = 265), we noted 190 cases (71.7%) without and 75 cases (28.3%) with Piwi-like 1 expression (Suppl. Table 1; Table 1).

    Table 1 Clinico-pathological data for RCC cohorts.

    Regarding the Piwi-like 1 IRS, there was no correlation with age, gender, tumor histology, tumor size or survival status (OS and CSS), but there was a significant positive correlation with Fuhrman grade (rs = 0.201), lymph node metastasis (rs = 0.276), distant metastasis (rs = 0.248), microvascular invasion (rs = 0.199), collecting duct invasion (rs = 0.203) (all P ≤ 0.001) and tumor stage (rs = 0.163; P = 0.008). We also detected a negative correlation with survival time (rs = −0.172; P = 0.005).

    To further assess these findings, we grouped the data for a cross tables analysis (Chi2 tests). Piwi-like 1 protein expression, as detected by IHC, was grouped as negative (IRS = 0) and positive (IRS > 0). We detected Piwi-like 1 protein expression more often in the tumor stages T3 + T4 than in T1 + 2 (P = 0.001), in the high Fuhrman grades 3 + 4 than in 1 + 2 (P < 0.001), in patients with microvascular invasion compared to patients without (P = 0.002), in patients with collecting duct invasion compared to patients without (P = 0.004), in patients with lymph node metastasis compared to patients without (P < 0.001), and in patients with distant metastasis than in patients without distant metastasis (P < 0.001).

    Cohort 2

    In cohort 2 (N = 345), we detected 294 cases (85.2%) without and 51 cases (14.8%) with Piwi-like 1 expression (Suppl. Table 1; Table 1). We found no correlation of the Piwi-like 1 IRS with age, gender, tumor histology, microvascular invasion or lymph node metastasis, but a significant positive correlation with Fuhrman grade (rs = 0.174; P = 0.001), survival status (CSS; rs = 0.185; P = 0.001), distant metastasis (rs = 0.153; P = 0.005), and tumor stage (rs = 0.132; P = 0.027), and a negative correlation with survival time (rs = -0.197; P < 0.001).

    To verify these findings further, we again grouped the data for a cross tables analysis (Chi2 tests). Piwi-like 1 positivity occurred more often in the high Fuhrman grades 3 + 4 than in 1 + 2 (P = 0.011), in the tumors of patients who died from a tumor specific cause (P < 0.001), and in tumors from patients with distant metastasis compared to patients without distant metastasis (P = 0.002).

    Altogether, in both cohorts, we validated a positive correlation of Piwi-like1 protein expression with higher Fuhrman grades, higher tumor stage and the occurrence of distant metastasis and a negative correlation with survival time.

    Piwi-like 1 protein expression and survival All the RCC patients

    In cohort 1, by the Kaplan-Meier analysis no significant association of Piwi-like 1 positivity with OS (P = 0.096) was observed, but a significant association with CSS (P = 0.032) was detected. The mean CSS time was 81.1 months for patients with Piwi-like 1 positive tumors vs. 101.5 months for patients with Piwi-like 1 negative tumors (Fig. 1). An univariate Cox’s regression analysis revealed that Piwi-like 1 expression was associated with an 1.59-fold increased risk of cancer-specific death (CSD) (P = 0.033) but not with a significantly increased risk of death from any cause (P = 0.098; Table 2). In the multivariate Cox’s regression analysis (adjusted to Fuhrman grade and tumor stage), Piwi-like 1 protein expression in the tumor was not identified as an independent predictor of OS or CSS (Table 2).

    Figure 1

    Kaplan-Meier analysis for overall (OS) and cancer specific survival (CSS) of all RCC patients in cohort 1 and cohort 2. In cohort 1 no significant association of Piwi-like 1 positivity with OS (P = 0.096) but a significant association with CSS (P = 0.032) was observed. In cohort 2 patients with Piwi-like 1 positive tumors showed a shorter OS (P = 0.001) and CSS (P < 0.001) than patients with Piwi-like 1 negative staining of their tumors. In this and all further survival analyses an IRS = 0 was considered as negative and an IRS > 0 as positive staining.

    Table 2 Univariate and multivariate Cox’s regression hazard analyses for all patients.

    In cohort 2, patients with Piwi-like 1 positive tumors showed a shorter OS and CSS. The mean OS time was 60.5 months for patients with Piwi-like 1 positive tumors vs. 101.7 months for patients with Piwi-like negative tumors (P = 0.001; Fig. 1). Concerning CSS, the patients with Piwi-like 1 positive tumors had a mean survival of 76.4 months vs. 131.9 months for the patients with Piwi-like 1 negative tumors (P < 0.001; Fig. 1). The univariate Cox’s regression analysis revealed that Piwi-like 1 positivity was associated with a 2.24-fold risk of death (P = 0.001) and a 4.37-fold increased risk for CSD (P < 0.001; Table 2). The multivariate Cox’s regression analysis (adjusted to Fuhrman grade and tumor stage) revealed that Piwi-like 1 positivity was an independent prognostic factor for OS (RR = 1.81; P = 0.024) and for CSS (RR = 3.09; P = 0.003; Table 2). However, when we included the presence of distant metastasis in the model, the tumor stage and Piwi-like 1 expression were no longer independent predictors of OS and CSS (data not shown).

    Stratification according to histological subtype

    Since it is known that tumor histology represents a major risk factor for outcome, we separately examined clear cell RCC, the most common histologic subtype.

    Cohort 1 (N = 198) consisted of 139 patients (70.2%) with Piwi-like 1 negative clear cell RCC tumors and 59 patients (29.8%) with Piwi-like 1 positive clear cell RCC tumors. Patients with Piwi-like 1 positive clear cell RCC exhibited an average CSS of 78.6 months compared to. 94.2 months for patients with Piwi-like 1 negative tumors, but the difference was not significant (P = 0.143).

    In cohort 2 (N = 274), 235 clear cell RCC patients (85.8%) were Piwi-like 1 negative, and 39 patients (14.2%) were Piwi-like 1 positive. The mean OS time for the Piwi-like 1 positive patients was 56.6 months vs. 101.7 months for the Piwi-like 1 negative patients (P < 0.001). Considering CSS, patients with Piwi-like 1 positive tumors had a mean survival of 69.9 months vs. 130.3 months for patients with Piwi-like 1 negative tumors (P < 0.001; Kaplan-Meier analysis Fig. 2). A univariate Cox’s regression analysis revealed that Piwi-like 1 positivity was associated with a 2.57-fold risk for death (P < 0.001) and a 5.10-fold increased risk for CSD (P < 0.001). A multivariate Cox’s regression analysis (adjusted for Fuhrman grade and tumor stage) confirmed that Piwi-like 1 positivity was an independent prognostic factor for OS (RR = 1.90; P = 0.023) and for CSS (RR = 3.19; P = 0.003). However, when the presence of distant metastases was included in the multifactorial model, tumor stage and Piwi-like 1 expression were no longer independent predictors of OS or CSS (data not shown).

    Figure 2

    Kaplan-Meier analysis for OS and CSS of the subgroup of clear cell RCC patients in cohort 2. Patients with Piwi-like 1 positive tumors showed a significant association with shorter OS and CSS (both P < 0.001) compared to patients with Piwi-like negative tumors.

    Stratification according to Fuhrman grade and WHO tumor grade

    Because of the correlation between Fuhrman grade and Piwi-like 1 protein expression, we tested if Piwi-like 1 positivity was a prognostic factor in the Fuhrman grade groups (grade1 + 2 or grade 3 + 4).

    In cohort 1, only patients with higher Fuhrman grade tumors (3 + 4; N = 36) showed differences in OS and CSS associated with Piwi-like 1 positivity. The mean OS and CSS intervals for the patients with Piwi-like 1 positive tumors were 16.3 months and 16.0 months, whereas those patients with Piwi-like 1 negative tumors survived on average 52.1 months and 58.6 months, respectively. This difference was significant for CSS only (P = 0.056 and P = 0.024; Fig. 3A).

    Figure 3

    Kaplan Meier analysis for CSS survival in the Fuhrman grade 3 + 4 group in cohort 1 and cohort 2. Patients with Piwi-like 1 positive tumors possessed a significant association with shorter CSS in (A) cohort 1 and (B) cohort 2 (P = 0.024 and P < 0.001). Kaplan-Meier analysis for OS and CSS in the tumor grade 2 + 3 group in cohort 2. Patients with Piwi-like 1 positive tumors revealed a significant association with shorter (C) OS and (D) CSS (P = 0.002 and P < 0.001).

    Likewise, in cohort 2, only patients with higher Fuhrman grade tumors (3 + 4; N = 113) showed differences in OS and CSS associated with Piwi-like 1 positivity. The mean OS and CSS intervals for patients with Piwi-like 1 positive tumors were 41.5 months and 46.9 months, whereas those patients with Piwi-like negative tumors had a mean survival of 65.0 months and 92.3 months. Again, the difference was significant for CSS only (P = 0.135 and P < 0.001; Fig. 3A).

    Taken together, Piwi-like1 expression sub-stratified RCC patients with high Fuhrman grade tumors into groups with shorter or longer CSS.

    Tumor grade according to WHO 201616 was determined for cohort 2 only. In this cohort, the patients with a higher tumor grade (2 + 3, N = 303) showed differences in OS and CSS associated with Piwi-like 1 protein expression. The mean OS and CSS intervals for the patients with Piwi-like 1 positive tumors were 58.4 months and 74.5 months, whereas those patients with Piwi-like negative tumors survived, on average, for 99.5 months and 130.2 months (P = 0.002 and P < 0.001; Fig. 3B).

    Stratification according to tumor stage

    Since there was a correlation between tumor stage and Piwi-like 1 protein expression, we analyzed if Piwi-like 1 positivity was a prognostic factor in the tumor stage groups (T1 + T2 vs. T3 + T4) of the RCC patients. In cohort 1, a difference in the OS between patients with Piwi-like 1 positive tumors and patients with the Piwi-like 1 negative tumors was detected in the T3 + T4 group only, but this was not significant (N = 90; 42.9 vs. 66.7 months; P = 0.052). Again, a difference in CSS between the patients with Piwi-like 1 positive tumors and the patients with Piwi-like 1 negative tumors (N = 89; 43.9 vs. 67.5 months; P = 0.044; Fig. 4) was found in the T3 + T4 group only.

    Figure 4

    Kaplan-Meier analysis for CSS in the tumor stage T3 + T4 group in cohort 1 and cohort 2. Patients with Piwi-like 1 positive tumors possessed a significant association with shorter CSS in cohort 1 and cohort 2 (P = 0.044 and P = 0.027).

    In cohort 2, there was a difference in OS between the patients with Piwi-like 1 positive tumors and the patients with Piwi-like 1 negative tumors in the T1 + T2 group (N = 250; 62.5 vs. 111.7 months; P < 0.001) but not in the T3 + T4 group (N = 85; 36.9 vs. 71.8 months; P = 0.176). An analysis of CSS between the patients with Piwi-like 1 positive tumors and the patients with negative tumors revealed significant differences in both tumor stage groups (T1 + T2 group: N = 250; 74.5 vs. 134.4 months; P < 0.001, and T3 + T4 group: N = 85; 55.0 vs. 121.7 months; P = 0.027; Fig. 4).

    Altogether, in both cohorts, Piwi-like 1 expression separated patients with higher tumor stage (T3 + T4) into groups with shorter or longer CSS.

    Stratification according to presence of distant metastases

    We demonstrated a correlation between the presence of distant metastasis and Piwi-like 1 expression. In cohort 1 there was a difference in CSS between the patients with Piwi-like 1 positive tumors and the patients with Piwi-like 1 negative tumors with distant metastasis (M1; N = 56) (28.3 vs. 41.0 months), but this was not significant (P = 0.65).

    In cohort 2, only the patients that developed distant metastases (N = 84) showed differences in OS and CSS in association with Piwi-like 1 expression. The mean OS and CSS intervals for the patients with Piwi-like 1 positive tumors were 28.8 months and 35.0 months, whereas the patients with Piwi-like 1 negative tumors survived, on average, for 57.8 months and 98.9 months (P = 0.035 and P < 0.001; Fig. 5).

    Figure 5

    Kaplan Meier analysis for OS and CSS in patients with distant metastasis in cohort 2. Patients with Piwi-like 1 positive tumors showed a significant association with shorter OS and CSS (P = 0.035 and P < 0.001).

    Stratification according to pre-operative C-reactive protein (CRP) levels

    We previously showed that pre-operative CRP levels are an independent prognostic factor for OS and CSS in RCC patients17. We therefore separated the RCC patients in two groups (low: <5 mg/ml vs. high: ≥5 mg/ml). This cutoff was chosen in accordance with routine clinical diagnostics, where a threshold of 5 mg/ml is routinely used. Moreover, 5 mg/ml was also the median in cohort 1 (N = 256). As expected, patients with low pre-operative CRP levels had a mean OS interval of 115.6 months and a mean CSS interval of 118.6 months, whereas those with high pre-operative CRP levels showed an average OS of 65.5 months and a CSS of 72.6 months (both P < 0.001).

    In cohort 1, Piwi-like 1 expression was associated with the OS and CSS intervals only in the subgroup with higher CRP values (≥5 mg/ml). Hereby, patients with Piwi-like 1 positive tumors had a mean OS of 46.2 months and a mean CSS of 48.8 months, whereas those with Piwi-like 1 negative tumors showed, on average, an OS of 73.5 months and a CSS of 81.7 months (P = 0.019 and P = 0.006; Fig. 6).

    Figure 6

    Kaplan-Meier analysis for OS and CSS in the CRP high group in cohort 1 and cohort 2. In cohort 1, patients with Piwi-like 1 positive tumors showed a shorter OS and CSS (P = 0.019 and P = 0.006). In addition in cohort 2, patients with Piwi-like 1 positive tumors revealed a shorter OS and CSS (P = 0.023 and P = 0.005).

    In cohort 2, like before, the patients were separated into low and high pre-operative CRP level groups (low: <5 mg/ml vs. high: ≥5 mg/ml). The patients with low pre-operative CRP levels had a mean OS of 64.1 months. Notably, none of the patients with low pre-operative CRP levels suffered a CSD. The patients with high pre-operative levels showed a mean OS of 44.8 months, and eight patients died of CSD (both P < 0.001).

    Stratified according to the defined CRP level groups, Piwi-like 1 expression was associated with differences in OS and CSS only in the high CRP group. Patients with Piwi-like 1 positive tumors had a mean OS of 26.7 months and a mean CSS of 34.8 months, whereas those with Piwi-like 1 negative tumors showed, on average, an OS of 50.4 months and a CSS of 68.0 months (P = 0.023 and P = 0.005; Fig. 6).

    Altogether, Piwi-like 1 expression further sub-stratified the patient population with high pre-operative CRP levels into patients with a shorter OS and CSS (Piwi-like 1 positive) and patients with a longer survival (Piwi-like 1 negative).


    Top 3 Price Prediction Bitcoin, Ripple, Ethereum: Failure At Key Levels Dyes The Market Red | killexams.com real questions and Pass4sure dumps

  • The script repeats itself and XRP enters a statistically pre-upward stage.
  • An exhausted market exaggerates the emotion amid minor falls.
  • The failure to overcome key levels is the origin of the falls.
  • Today we are dawning in Europe with widespread falls on the Crypto board. At the time of writing, all three main assets are losing critical supports.

    However, the ETH/BTC pair has lost the uptrend line and is now looking for the next, lower but similarly uptrend inclination. The behavior of the ETH/BTC is key in the crypto market, as important as it marks the direction of the market.

    eth_btc_21-636850478859311070.png

    Cryptocurrencies falling? The money moves towards Bitcoin in a flight to quality or confidence. Cryptos rising? Money rotates towards Altcoins looking for Beta.

    Today, we may possibly see more generalized price falls in the crypto segment, which can be extended further in time if certain key levels are drilled.

    BTC/USD 240 Minute Chart

    The BTC/USD pair is currently trading at the $3.373 price level after attempting to cross the EMA50 unsuccessfully during the Asian session. After more than 58 weeks of falls, the failure falls like a jug of cold water, but the BTC/USD only lost $70, a fraction as far as the daily range is concerned when it comes to Bitcoin.

    Of course, the headlines of the day place the future value of the BTC/USD at around $1,000 and open the full the doors of the apocalypse - A panicky environment that brings us closer to the final capitulation point.

    In today's chart, I have drawn a bearish channel that understands the bearish movement since mid-December, and that will help us find the action points in the short term.

    Below the current price, the BTC/USD pair does not have much margin within the bearish channel. The first support level is at the price level of $3,360 (price congestion support), while the second support level is at $3,300 (price congestion support). Below this support level is the lower trend line of the channel that will be active at least until February 12. The breakage of the downstream channel would be worrying since Bitcoin would lose the frame of reference and the panic would then be entirely justified. The price level of this trend line is between $3,270 and $3,210 for the next six days.

    Above the current price, the clear objective has been the executioner of today, the exponential moving average of 50 periods. Between the current rate and the level through which this exponential average passes there is a price congestion resistance level of $3,400. As the crucial second level of resistance to conquer it is $3,470 (SMA100 and price congestion resistance). The roof of the downstream channel is between $3,770 and $3,700 for the next six days.

    btc_usd_72-636850479957484006.png

    The MACD on the 4-hour chart leans lower and manages to open a gap between the lines. The movement is minimal concerning the fall in price, so we must wait at least until the end of today to accurately assess the possible development of the MACD in the following days.

    The DMI on the 4-hour chart shows bears reacting strongly to the bearish movement. The bulls, on the other hand, retreat a little, but not to the same extent that the bears have gained ground. Both sides of the market remain above the ADX, which increases the chances of violent price swings in both directions.

    ETH/USD 240 Minute Chart

    The ETH/USD is currently trading at the $102.5 price level, already losing more than 30% from the price levels seen earlier this year. Early in the day, in the Asian session, ETH/USD has reached levels not seen since late December, hitting a low at $101.12.

    The ETH/USD also failed yesterday in its attempt to cross upward the EMA50 and now struggles not to lose price congestion support at $102. Below this support level, the second support level is at the psychological level of $100 (price congestion support). The third level of support is at $98 (price congestion support). I want to highlight how the long bearish sideways movement is creating congestion levels very close together on the price scale. An authentic wall of support or resistance, depending on which side the ETH/USD ends on.

    Above the current price, the technical targets are similar to the BTC/USD pair. Until we reach the EMA50 which is at $107.5, there is a level of congestion per price at $105.5 (price congestion resistance). The next hurdle is a little higher, at the $110 price level, there is another price congestion resistance and the SMA100. The simple average of 200 periods moves at the price level of $123 and is the definitive point to be able to affirm that a change in trend has been consolidated.

    1eth_usd_59-636850480761243381.png

    The MACD on the 4-hour chart shows a slight bearish profile with hardly any distance between the lines that make up this indicator. The potential to create a significant divergence is high.

    The DMI on the 4-hour chart shows bears reacting strongly to falls while bulls weaken more here than in the case of Bitcoin. Bullseyes are placed below the ADX and lose bull potential.

    XRP/USD 240 Minute Chart

    The XRP/USD is currently trading at the $0.289 price level and is dangerously close to the lows seen at the end of January. The drop from the relative highs of last January 31st is already more than 20%. The XRP does not drop as a result of a failed attempt to cross the EMA50, as just four days ago it pierced the EMA50 and the SMA100 without difficulty, even reaching the price level of the SMA200.

    Below the current price, the first support is at $0.288 (price congestion support). This support has very little chance of resisting. The second level of support is at $0.285 (price congestion support) while the third level is at the price level of $0.282 (price congestion support).

    Above the current price, the first resistance level is $0.293 (price congestion resistance) but the primary objective, the 50-period exponential moving average is well above $0.303. At the second resistance level, which is at the price level of $0.308 (price congestion resistance and SMA100). The simple average of 200 periods is $0.325.

    xrp_usd_62-636850481461107339.png

    The MACD on the 4-hour chart shows a typical chart structure pattern. There is a MACD failure. Statistically, an upturn should occur in the next few hours.

    The 4-hour DMI graph also shows in the case of the XRP the bears taking control of the situation. The bulls retreat slightly and stay above the ADX line. 



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